All Outputs (3)

A CRISPR-Cas9 sex-ratio distortion system for genetic control (2016)
Journal Article
Galizi, R., Hammond, A., Kyrou, K., Taxiarchi, C., Bernardini, F., O’Loughlin, S. M., …Crisanti, A. (2016). A CRISPR-Cas9 sex-ratio distortion system for genetic control. Scientific Reports, 31139 - ?. https://doi.org/10.1038/srep31139

Genetic control aims to reduce the ability of insect pest populations to cause harm via the release of modified insects. One strategy is to bias the reproductive sex ratio towards males so that a population decreases in size or is eliminated altogeth... Read More about A CRISPR-Cas9 sex-ratio distortion system for genetic control.

Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. (2016)
Journal Article
Brantley Hall, A., Papathanos, P., Sharma, A., Cheng, C., Akbari, O. S., Assour, L., …Besansky, N. J. (2016). Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. Proceedings of the National Academy of Sciences of the United States of America, E2114 - E2123. https://doi.org/10.1073/pnas.1525164113

Y chromosomes control essential male functions in many species, including sex determination and fertility. However, because of obstacles posed by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model organi... Read More about Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes..

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae (2016)
Journal Article
Hammond, A., Galizi, R., Kyrou, K., Simoni, A., Siniscalchi, C., Katsanos, D., …Nolan, T. (2016). A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology, 78 - 83. https://doi.org/10.1038/nbt.3439

Gene drive systems that enable super-Mendelian inheritance of a transgene have the potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 endonuclease constructs that function as gene drive systems in Anophele... Read More about A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae.