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All Outputs (329)

Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis (2017)
Journal Article
Prior, J. A., Ranjbar, H., Belcher, J., Mackie, S. L., Helliwell, T., Liddle, J., & Mallen, C. D. (2017). Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis. BMC Medicine, 15, Article 120. https://doi.org/10.1186/s12916-017-0871-z

BACKGROUND: Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study's objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific cha... Read More about Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis.

The role of environmental factors for the onset of restricted mobility outside the home among older adults with osteoarthritis: a prospective cohort study (2017)
Journal Article
Rantakokko, M., & Wilkie, R. (2017). The role of environmental factors for the onset of restricted mobility outside the home among older adults with osteoarthritis: a prospective cohort study. BMJ Open, 7(6), e012826 -?. https://doi.org/10.1136/bmjopen-2016-012826

OBJECTIVES: The study examines how environmental factors contribute to the onset of restricted mobility outside the home among older adults with osteoarthritis. METHODS: This is a prospective cohort study of adults aged 50 years and older with osteoa... Read More about The role of environmental factors for the onset of restricted mobility outside the home among older adults with osteoarthritis: a prospective cohort study.

Anniversary Collection: 35 Years of STEM CELLS Homing of Mesenchymal Stem Cells An Update to: Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing (2017)
Journal Article
Kehoe, O., Fox, J. M., & Middleton, J. (2017). Anniversary Collection: 35 Years of STEM CELLS Homing of Mesenchymal Stem Cells An Update to: Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing. Journal of Stem Cells,

Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score. (2017)
Journal Article
(2017). Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score. European Respiratory Journal, https://doi.org/10.1183/13993003.02191-2016

Chronic obstructive pulmonary disease (COPD) is greatly underdiagnosed worldwide and more efficient methods of case-finding are required. We developed and externally validated a risk score to identify undiagnosed COPD using primary care records.We co... Read More about Predicting risk of undiagnosed COPD: development and validation of the TargetCOPD score..

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. (2017)
Journal Article
Kwong. (2017). A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR. Oncogene, 3576 - 3587. https://doi.org/10.1038/onc.2016.509

Peritoneum is the most common site for ovarian cancer metastasis. Here we investigate how cancer epigenetics regulates reciprocal tumor-stromal interactions in peritoneal metastasis of ovarian cancer. Firstly, we find that omental stromal fibroblasts... Read More about A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFa-TGFa-EGFR..

Effective treatment options for musculoskeletal pain in primary care: A systematic overview of current evidence (2017)
Journal Article
Babatunde, O., Jordan, J., Van Der Windt, D., Hill, J., Foster, N. E., & Protheroe, J. (2017). Effective treatment options for musculoskeletal pain in primary care: A systematic overview of current evidence. PLoS ONE, 12(6), Article e0178621. https://doi.org/10.1371/journal.pone.0178621

Background & aims
Musculoskeletal pain, the most common cause of disability globally, is most frequently managed in primary care. People with musculoskeletal pain in different body regions share similar characteristics, prognosis, and may respond to... Read More about Effective treatment options for musculoskeletal pain in primary care: A systematic overview of current evidence.

Management of shoulder pain by UK general practitioners (GPs): a national survey (2017)
Journal Article
Roddy, & Van Der Windt. (2017). Management of shoulder pain by UK general practitioners (GPs): a national survey. BMJ Open, e015711 -?. https://doi.org/10.1136/bmjopen-2016-015711

OBJECTIVES: Studies in Canada, the USA and Australia suggested low confidence among general practitioners (GPs) in diagnosing and managing shoulder pain, with frequent use of investigations. There are no comparable studies in the UK; our objective wa... Read More about Management of shoulder pain by UK general practitioners (GPs): a national survey.

Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care (2017)
Journal Article
Cawley, A., Prior, J., Muller, S., Helliwell, T., Hider, S., Dasgupta, B., …Mallen, C. (2017). Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care. Clinical Rheumatology, 37(6), 1639-1644. https://doi.org/10.1007/s10067-017-3730-6

This paper aims to examine the relationship between different characteristics of pain and stiffness and the functional status of patients with newly diagnosed polymyalgia rheumatica (PMR). Baseline analysis of an inception cohort study was conducted.... Read More about Association between characteristics of pain and stiffness and the functional status of patients with incident polymyalgia rheumatica from primary care.

GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey (2017)
Journal Article
Roddy, E., Cottrell, E., Foster, N. E., Porcheret, M., & Rathod, T. (2017). GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey. BMJ Open, 7(6), e014999 - ?. https://doi.org/10.1136/bmjopen-2016-014999

OBJECTIVES:
The aim of this study was to investigate general practitioners' (GPs) attitudes, beliefs and behaviours regarding the use of exercise for patients with chronic knee pain (CKP) attributable to osteoarthritis.

SETTING: Primary care GPs... Read More about GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey.

Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial (2017)
Journal Article
Jinks, C., Nicholls, E., Liddle, J., Healey, E., Evans, A., Chew-Graham, C., …Team, E. (2017). Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial. Annals of the Rheumatic Diseases, 76(S2), 1433-1433. https://doi.org/10.1136/annrheumdis-2017-eular.2473

Background Co-morbid osteoarthritis (OA), anxiety and depression are undermanaged in primary care yet have significant impact on pain, disability and outcomes of other long-term conditions (LTCs).

Objectives To test the feasibility and acceptabili... Read More about Integrating case finding and initial management for osteoarthritis, anxiety and depression into routine primary care nurse-led long-term condition reviews: results from the enhance pilot trial.

FRI0456 Age at spondyloarthritis diagnosis and risk of cardiovascular comorbidity: results from the comospa study (2017)
Presentation / Conference
Derakhshan, M., Goodson, N., Packham, J., Sengupta, R., Marzo-Ortega, H., Molto, A., & Siebert, S. (2017, June). FRI0456 Age at spondyloarthritis diagnosis and risk of cardiovascular comorbidity: results from the comospa study. Poster presented at EULAR 2017, Madrid, Spain

Background
Spondyloarthritis (SpA) and chronic inflammatory diseases are associated with a number of cardiovascular comorbidities. It is unknown whether age at SpA diagnosis is associated with cardiovascular outco... Read More about FRI0456 Age at spondyloarthritis diagnosis and risk of cardiovascular comorbidity: results from the comospa study.

THU0614 Fidelity of an intervention to increase physical activity in older adults with chronic pain: analysis of audio-recorded consultations from the ipopp pilot trial (2017)
Presentation / Conference
Jinks, C., Proctor, J., Healey, E., McBeth, J., Graham, C. C., & team, I. (2017, June). THU0614 Fidelity of an intervention to increase physical activity in older adults with chronic pain: analysis of audio-recorded consultations from the ipopp pilot trial. Poster presented at Annual European Congress of Rheumatology, 14–17 June, 2017, Madrid, Spain

Background Physical activity levels are low in people >65 years and those with chronic musculoskeletal pain, yet increased physical activity can lead to reduced pain. Walking is acceptable to older people with pain, but interventions to increase walk... Read More about THU0614 Fidelity of an intervention to increase physical activity in older adults with chronic pain: analysis of audio-recorded consultations from the ipopp pilot trial.

NO TREATMENT EFFECTS OF ORAL GLUCOSAMINE FOR SUBGROUPS OF KNEE AND HIP OSTEOARTHRITIS PATIENTS; AN INDIVIDUAL PATIENT DATA META-ANALYSIS FROM THE OA TRIAL BANK (2017)
Presentation / Conference
Runhaar, J., Rozendaal, R., van Middelkoop, M., Bijlsma, J., Doherty, M., Dziedzic, K., …Bierma-Zeinstra, S. (2017, June). NO TREATMENT EFFECTS OF ORAL GLUCOSAMINE FOR SUBGROUPS OF KNEE AND HIP OSTEOARTHRITIS PATIENTS; AN INDIVIDUAL PATIENT DATA META-ANALYSIS FROM THE OA TRIAL BANK. Poster presented at EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain

Background The effectiveness of oral glucosamine for symptoms of osteoarthritis (OA) is debated. Individual trials are not powered to show effects within subgroups of patients.

Objectives To evaluate the effectiveness of oral glucosamine in clinic... Read More about NO TREATMENT EFFECTS OF ORAL GLUCOSAMINE FOR SUBGROUPS OF KNEE AND HIP OSTEOARTHRITIS PATIENTS; AN INDIVIDUAL PATIENT DATA META-ANALYSIS FROM THE OA TRIAL BANK.

SAT0708 Symptoms indicative of inflammatory arthritis are common in the primary care population: findings from the symptoms in persons at risk of rheumatoid arthritis survey (2017)
Presentation / Conference
Hider, S., Muller, S., Prior, J., Helliwell, T., Schaardenburg, D. V., Mil, A. V. D. H., …Mallen, C. (2017, June). SAT0708 Symptoms indicative of inflammatory arthritis are common in the primary care population: findings from the symptoms in persons at risk of rheumatoid arthritis survey. Paper presented at Annual European Congress of Rheumatology, 14–17 June, 2017

SAT0672 Risk of fragility fracture among patients with psoriasis: a population based matched cohort study from the united kingdom (2017)
Presentation / Conference
Paskins, Z., Whittle, R., Sultan, A. A., Muller, S., Helliwell, T., Blagojevic-Bucknall, M., …Mallen, C. (2017, June). SAT0672 Risk of fragility fracture among patients with psoriasis: a population based matched cohort study from the united kingdom. Poster presented at Annual European Congress of Rheumatology, 14–17 June, 2017