Skip to main content

Research Repository

Advanced Search

All Outputs (1441)

The interplay between TP53 and mevalonate pathway in ovarian cancer (2017)
Journal Article
Abdullah, M., Abed, M., & Richardson, A. (2017). The interplay between TP53 and mevalonate pathway in ovarian cancer. Annals of Oncology, 28(S5), v6. https://doi.org/10.1093/annonc/mdx361.020

Background: TP53 gene is the most commonly mutated tumour suppressor in human malignancies. TP53 is mutated in more than 50% of all human cancers, with over 96% of high-grade serous ovarian cancer displaying changes at this locus. Mutations of TP53 g... Read More about The interplay between TP53 and mevalonate pathway in ovarian cancer.

P31 Role of sesquiterpene lactones against human ovarian cancer (2017)
Journal Article
Fadayomi, I. E., Forsyth, N., & Li, W. (2017). P31 Role of sesquiterpene lactones against human ovarian cancer. Biochemical Pharmacology, 139(11), 134-135. https://doi.org/10.1016/j.bcp.2017.06.032

Background:
Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about P31 Role of sesquiterpene lactones against human ovarian cancer.

Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011. (2017)
Journal Article
A, C., M, R., MJ, H., SU, K., MS, H., R, S., …K, S. (2017). Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011. Journal of Infectious Diseases, S520 - S528. https://doi.org/10.1093/infdis/jix019

Background
In March 2011, a multidisciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infection, detected through population-based active surveillance for influenza in Bangladesh, to assess transmission and... Read More about Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011..

Pain and learning in primary school: a population-based study (2017)
Journal Article
Kosola, S., Mundy, L. K., Sawyer, S. M., Canterford, L., van der Windt, D. A., Dunn, K. M., & Patton, G. C. (2017). Pain and learning in primary school: a population-based study. PAIN, 158(9), 1825-1830. https://doi.org/10.1097/j.pain.0000000000000984

Despite the frequency of pain among children, little is known about its effects on learning and school outcomes. The objective of this study was to quantify the association of pain and academic achievement while taking into account the presence of co... Read More about Pain and learning in primary school: a population-based study.

Understanding cultural influences on back pain and back pain research (2017)
Journal Article
(2017). Understanding cultural influences on back pain and back pain research. Best Practice and Research: Clinical Rheumatology, https://doi.org/10.1016/j.berh.2017.08.004

Low back pain is highly prevalent and places a considerable burden on individuals, their families and communities. This back pain burden is unequally distributed around the world and within populations. Clinicians and researchers addressing back pain... Read More about Understanding cultural influences on back pain and back pain research.

Mediators of Treatment Effect in the Back In Action Trial: Using Latent Growth Modeling to Take Change Over Time into Account. (2017)
Journal Article
Mansell, G., Hill, J., Main, C. J., Von Korff, M., & Van Der Windt, D. (2017). Mediators of Treatment Effect in the Back In Action Trial: Using Latent Growth Modeling to Take Change Over Time into Account. Clinical Journal of Pain, 33(9), 811-819. https://doi.org/10.1097/AJP.0000000000000463

OBJECTIVES: To test whether change in fear-avoidance beliefs was a mediator of the effect of treatment on disability outcome; To test an analytical approach, latent growth modelling, not often applied to mediation analysis.

METHODS: Secondary ana... Read More about Mediators of Treatment Effect in the Back In Action Trial: Using Latent Growth Modeling to Take Change Over Time into Account..

Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. (2017)
Journal Article
Mamas. (2017). Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres. BMJ Open, e016866 - ?. https://doi.org/10.1136/bmjopen-2017-016866

OBJECTIVES: The effect of weekend versus weekday admission following acute coronary syndrome (ACS) on process of care and mortality remains controversial. This study aimed to investigate the 'weekend-effect' on outcomes using a multicentre dataset of... Read More about Effect of weekend admission on process of care and clinical outcomes for the management of acute coronary syndromes: a retrospective analysis of three UK centres..

Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study. (2017)
Journal Article
Spiers, J., Buszewicz, M., Chew-Graham, C. A., Gerada, C., Kessler, D., Leggett, N., …Riley, R. (2017). Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study. British Journal of General Practice (BJGP), 700-708. https://doi.org/10.3399/bjgp17X692573

BACKGROUND: GPs are under increasing pressure due to a lack of resources, a diminishing workforce, and rising patient demand. As a result, they may feel stressed, burnt out, anxious, or depressed. AIM: To establish what might help or hinder GPs exper... Read More about Barriers, facilitators, and survival strategies for GPs seeking treatment for distress: a qualitative study..

Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo (2017)
Journal Article
Llavero Hurtado, M., Fuller, H., Wong, A., Eaton, S., Gillingwater, T., Pennetta, G., …Wishart, T. (2017). Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo. Scientific reports, https://doi.org/10.1038/s41598-017-12603-0

Synapses are an early pathological target in many neurodegenerative diseases ranging from well-known adult onset conditions such as Alzheimer and Parkinson disease to neurodegenerative conditions of childhood such as spinal muscular atrophy (SMA) and... Read More about Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo.

The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control (2017)
Journal Article
Dunn, K., Campbell, P., & Hope, K. (2017). The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control. Journal of Pain Research, https://doi.org/10.2147/JPR.S139445

Low back pain (LBP) is common, impacts on the individual and society, and is a major health concern. Psychological consequences of LBP, such as depression, are significant barriers to recovery, but mechanisms for the development of depression are les... Read More about The pain, depression, disability pathway in those with low back pain: a moderation analysis of health locus of control.

Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines (2017)
Presentation / Conference
Rosa Johnson-Ajinwo, O., Richardson, A., & Li, W. (2017, September). Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines. Presented at IUPHAR, Aberdeen

Ovarian cancer is the second leading cause of death among women in the gynaecological category of cancers. The current post surgery treatment which involves the use of platinum-based therapy with its attendant adverse drug-resistance often results in... Read More about Identification and evaluation of anticancer compounds from three Nigerian plants used in traditional medicines.

Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach? (2017)
Journal Article
Pearson, R. J. (2017). Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach?. Journal of Chemical Education, 94(12), 1866-1872. https://doi.org/10.1021/acs.jchemed.7b00270

Different approaches to the use of “clickers” (also known as student response systems) were introduced to a cohort of 127 students over a two-year period with the aim of making students think more deeply in-class about their chemistry knowledge. Stud... Read More about Tailoring Clicker Technology to Problem-Based Learning: What’s the Best Approach?.

Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. (2017)
Journal Article
Sim, J., Bishop, J., Gray, R., and the Stroke Oxygen Study Collaborative Group, S. O. S. I., Roffe, C., Nevatte, T., …Ferdinand, P. (2017). Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. Journal of the American Medical Association, 318(12), 1125 - 1135. https://doi.org/10.1001/jama.2017.11463

Importance: Hypoxia is common in the first few days after acute stroke, is frequently intermittent, and is often undetected. Oxygen supplementation could prevent hypoxia and secondary neurological deterioration and thus has the potential to improve r... Read More about Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial..