Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.
(2017)
Journal Article
Tang, H., Leung, L., Saturno, G., Viros, A., Smith, D., Di Leva, G., …Marais, R. (2017). Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface. Nature communications, 8, Article 14909. https://doi.org/10.1038/ncomms14909
Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumo... Read More about Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface..