All Outputs (5)

The role of heparan sulfate in host macrophage infection by Leishmania species (2018)
Journal Article
Maciej-Hulme, M., Skidmore, M., & Price, H. (2018). The role of heparan sulfate in host macrophage infection by Leishmania species. Transactions, 46(4), 789-796. https://doi.org/10.1042/BST20170398

The leishmaniases are a group of neglected tropical diseases caused by parasites from the Leishmania genus. More than 20 Leishmania species are responsible for human disease, causing a broad spectrum of symptoms ranging from cutaneous lesions to a fa... Read More about The role of heparan sulfate in host macrophage infection by Leishmania species.

Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease (2018)
Journal Article
Mycroft-West, C. J., Yates, E. A., & Skidmore, M. A. (2018). Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease. Biochemical Society Transactions, 46(4), 919-929. https://doi.org/10.1042/bst20170404

Glycosaminoglycans (GAGs), present in the extracellular matrix, are exploited by numerous, distinct microbes for cellular attachment, adhesion, invasion and evasion of the host immune system. Glycosaminoglycans, including the widely used, clinical an... Read More about Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease.

An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy (2018)
Journal Article
Holman, J., Skidmore, M., & Yates, E. (2018). An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy. Plasma, 1(1), 78-79. https://doi.org/10.3390/plasma1010008

Since signal/noise ratios are proportional to the square root of the intensity, high intensity light sources are advantageous for many forms of UV–Vis and IR spectroscopy particularly with very low or high absorbance samples. We report the constructi... Read More about An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy.

Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection (2018)
Journal Article
Vicenzi, E., Pagani, I., Ghezzi, S., Taylor, S. L., Rudd, T. R., Lima, M. A., …Yates, E. A. (2018). Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection. Biochemical Society Transactions, 46, 609-617. https://doi.org/10.1042/BST20170399

Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, ce... Read More about Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection.

Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans (2018)
Journal Article
Rogerson, E., Pelletier, J., Acosta-Serrano, A., Rose, C., Taylor, S., Guimond, S., …Yates, E. (2018). Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans. Pathogens an international, open access journal of pathogens and pathogen-host interactions, 7, https://doi.org/10.3390/pathogens7010032

Tsetse flies are the principal insect vectors of African trypanosomes-sleeping sickness in humans and Nagana in cattle. One of the tsetse fly species, Glossina morsitans morsitans, is host to the parasite, Trypanosoma brucei, a major cause of African... Read More about Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans.