The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents

Mbye, H; Richardson, A; Li, W; Horrocks, P; Johnson-Ajinwo, O; Ullah, I

doi:10.1016/j.bmcl.2018.02.051

All Outputs (5)

Modification of metal surfaces using TCM-derived cyclotides: an antibacterial and antibiofilm study (2018)
Presentation / Conference
Cao, P., Yang, Y., Uche, F. I., Hart, S., Yuan, C., & Li, W. (2018, August). Modification of metal surfaces using TCM-derived cyclotides: an antibacterial and antibiofilm study. Paper presented at 35th European Peptide Symposium, The Helix Conference Centre, Dublin City University, Ireland

Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells (2018)
Journal Article
Uche, F., McCullagh, J., Claridge, T., Richardson, A., & Li, W. (2018). Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells. Bioorganic and Medicinal Chemistry Letters, 1652-1656. https://doi.org/10.1016/j.bmcl.2018.03.038

Our previous studies demonstrated that cycleanine, a macrocyclic bisbenzylisoquinoline (BBIQ) alkaloid, showed potent anti-ovarian cancer activity via apoptosis induction. Here, we synthesized two novel (aminoalkyl) cycleanine analogues (2 and 3) thr... Read More about Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells.

Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study (2018)
Journal Article
Cao, P., Yang, Y., Ijeoma Uche, F., Ruth Hart, S., Li, W., & Yuan, C. (2018). Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study. International Journal of Molecular Sciences, 793 - 793. https://doi.org/10.3390/ijms19030793

Modification of metal surfaces with antimicrobial peptides is a promising approach to reduce bacterial adhesion. Here, cyclic peptides or cycloids, possessing remarkable stability and antimicrobial activities, were extracted and purified from Viola p... Read More about Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study.

Investigation of the antibiofilm capacity of peptide-modified stainless steel (2018)
Journal Article
Cao, P., Li, W., Morris, A. R., Horrocks, P. D., Yuan, C., & Yang, Y. (2018). Investigation of the antibiofilm capacity of peptide-modified stainless steel. Royal Society Open Science, https://doi.org/10.1098/rsos.172165

Biofilm formation on surfaces is an important research topic in ship tribology and medical implants. In this study, dopamine and two types of synthetic peptides were designed and attached to 304 stainless steel surfaces, aiming to inhibit the formati... Read More about Investigation of the antibiofilm capacity of peptide-modified stainless steel.

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents (2018)
Journal Article
Mbye, H., Richardson, A., Li, W., Horrocks, P., Johnson-Ajinwo, O., & Ullah, I. (2018). The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2018.02.051

Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the human malarial para... Read More about The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.