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Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. (2018)
Journal Article
Owida, H., Rutter, A., Cinque, G., Kuiper, N., Sule-Suso, J., & Yang, Y. (2018). Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. Analyst, 5979-5986. https://doi.org/10.1039/c8an01272e

Isolated and monolayer expanded chondrocytes are not the ideal cell form to produce a cartilage matrix. In articular cartilage, each chondrocyte is surrounded by a 2-4 µm thick collagen VI-rich pericellular matrix (PCM) forming a chondron. Freshly ex... Read More about Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model..

Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds. (2018)
Journal Article
Yang. (2018). Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds. Interface, https://doi.org/10.1098/rsif.2018.0310

Cartilage is anisotropic in nature and organized into distinct zones. Our goal was to develop zonal-specific three-dimensional hybrid scaffolds which could induce the generation of zonal-specific cellular morphology and extracellular matrix (ECM) com... Read More about Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds..

The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models (2018)
Journal Article
Yang. (2018). The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models. Colloids and Surfaces B: Biointerfaces, https://doi.org/10.1016/j.colsurfb.2018.04.060

The purpose of this work was to investigate if the biomimetically conjugated VEGF and HUVECs co-culture could modulate the osteogenic and angiogenic differentiation of MSCs derived from rat and human bone marrow (rMSCs and hMSCs). After treated by am... Read More about The Effects of Biomimetically Conjugated VEGF on Osteogenesis and Angiogenesis of MSCs (Human and Rat) and HUVECs Co-culture Models.

Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study (2018)
Journal Article
Cao, P., Yang, Y., Ijeoma Uche, F., Ruth Hart, S., Li, W., & Yuan, C. (2018). Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study. International Journal of Molecular Sciences, 793 - 793. https://doi.org/10.3390/ijms19030793

Modification of metal surfaces with antimicrobial peptides is a promising approach to reduce bacterial adhesion. Here, cyclic peptides or cycloids, possessing remarkable stability and antimicrobial activities, were extracted and purified from Viola p... Read More about Coupling Plant-Derived Cyclotides to Metal Surfaces: An Antibacterial and Antibiofilm Study.

Investigation of the antibiofilm capacity of peptide-modified stainless steel (2018)
Journal Article
Cao, P., Li, W., Morris, A. R., Horrocks, P. D., Yuan, C., & Yang, Y. (2018). Investigation of the antibiofilm capacity of peptide-modified stainless steel. Royal Society Open Science, https://doi.org/10.1098/rsos.172165

Biofilm formation on surfaces is an important research topic in ship tribology and medical implants. In this study, dopamine and two types of synthetic peptides were designed and attached to 304 stainless steel surfaces, aiming to inhibit the formati... Read More about Investigation of the antibiofilm capacity of peptide-modified stainless steel.

Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy (2018)
Journal Article
Yang. (2018). Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Methods, 126-133. https://doi.org/10.1016/j.ymeth.2017.10.010

Cell mechanical behaviour is increasingly recognised as a central biophysical parameter in cancer and stem cell research, and methods of investigating their mechanical behaviour are therefore needed. We have developed a novel qualitative method based... Read More about Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy.