All Outputs (3)

Iron stored in ferritin is chemically reduced in the presence of aggregating Aß(1-42). (2020)
Journal Article
Everett, J., Brooks, J., Lermyte, F., O’Connor, P. B., Sadler, P. J., Dobson, J., …Telling, N. D. (2020). Iron stored in ferritin is chemically reduced in the presence of aggregating Aß(1-42). Scientific reports, 20, Article 10332. https://doi.org/10.1038/s41598-020-67117-z

Atypical low-oxidation-state iron phases in Alzheimer's disease (AD) pathology are implicated in disease pathogenesis, as they may promote elevated redox activity and convey toxicity. However, the origin of low-oxidation-state iron and the pathways r... Read More about Iron stored in ferritin is chemically reduced in the presence of aggregating Aß(1-42)..

Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. (2020)
Journal Article
Brooks, J., Everett, J., Lermyte, F., Tjendana Tjhin, V., Sadler, P. J., Telling, N., & Collingwood, J. F. (2020). Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy. Journal of Trace Elements in Medicine and Biology, 62, Article 126555. https://doi.org/10.1016/j.jtemb.2020.126555

BACKGROUND: Neuromelanin-pigmented neurons, which are highly susceptible to neurodegeneration in the Parkinson's disease substantia nigra, harbour elevated iron levels in the diseased state. Whilst it is widely believed that neuronal iron is stored i... Read More about Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy..

Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. (2020)
Journal Article
Telling, & Everett. (2020). Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202000239

A hallmark of Parkinson's disease is the death of neuromelanin-pigmented neurons, but the role of neuromelanin is unclear. The in situ characterization of neuromelanin remains dependent on detectable pigmentation, rather than direct quantification of... Read More about Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy..