All Outputs (1749)

ARF regulating proteins as novel drug targets in Trypanosoma brucei (2020)
Thesis
Chandrathas, J. P. (2020). ARF regulating proteins as novel drug targets in Trypanosoma brucei. (Thesis). Keele University

Human African Trypanosomiasis (HAT) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases that pose a huge socioeconomic and health burden in poorer countries in sub-Saharan Africa. The causative agents of these diseases are the Tr... Read More about ARF regulating proteins as novel drug targets in Trypanosoma brucei.

Essays on contagion analysis in a small open petroleum economy (2020)
Thesis
Mahadeo, S. M. R. (2020). Essays on contagion analysis in a small open petroleum economy. (Thesis). Keele University

This thesis focuses on how the relationships between the financial markets of the small open energy economy of Trinidad and Tobago and relevant foreign markets evolve, under alternative stable and unstable international market conditions. The researc... Read More about Essays on contagion analysis in a small open petroleum economy.

Xenoliths as tracers of magmatic and intra-crustal processes at volcanic arcs (2020)
Thesis
Whitley, S. O. (2020). Xenoliths as tracers of magmatic and intra-crustal processes at volcanic arcs. (Thesis). Keele University

Arc magmas typically show distinct geochemical and petrographical evidence indicating a complex petrogenesis. The surface products represent a summation of the complex interplay of geodynamic magma generation processes, varied differentiation histori... Read More about Xenoliths as tracers of magmatic and intra-crustal processes at volcanic arcs.

The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2 (2020)
Thesis
Benn, E. E. (2020). The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2. (Thesis). Keele University

The negative ways in which diabetes affects the brain, and the role of neural insulin and glucose is an interesting research topic as research has shown a correlation between neurodegenerative diseases and diabetes. This thesis focuses on how polyuns... Read More about The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2.

The impact of the governance of health insurance companies on patient satisfaction with hospitals in Saudi Arabia (2020)
Thesis
Alzahrani, A. H. (2020). The impact of the governance of health insurance companies on patient satisfaction with hospitals in Saudi Arabia. (Thesis). Keele University

The aim of this research study is to investigate the impact of corporate-governance-related practices on the effectiveness of health insurance companies, and in turn, their impact upon the performance of hospitals as measured by patients’ satisfactio... Read More about The impact of the governance of health insurance companies on patient satisfaction with hospitals in Saudi Arabia.

The ethical accommodation of patients’ religious beliefs in healthcare: a care respect framework prompted by examples from modern Paganism (2020)
Thesis
Griffin, S. J. M. (2020). The ethical accommodation of patients’ religious beliefs in healthcare: a care respect framework prompted by examples from modern Paganism. (Thesis). Keele University

Conflicts of values arise between the values of healthcare staff, and the values of some religious patients. The reasons why, and the extent to which, patient beliefs and values ought to be accommodated has been a feature of the ethics literature for... Read More about The ethical accommodation of patients’ religious beliefs in healthcare: a care respect framework prompted by examples from modern Paganism.

Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer (2020)
Thesis
Ali Asgari, M. (2020). Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is the 4th most aggressive cancer in the Western world. There are very little drugs available as chemotherapies for the treatment of pancreatic cancer. Of the ones used, most of them become eliminated by first pass metabolism before... Read More about Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer.

Evolving developmental, recurrent and convolutional neural networks for deliberate motion planning in sparse reward tasks (2020)
Thesis
Jolley, B. P. (2020). Evolving developmental, recurrent and convolutional neural networks for deliberate motion planning in sparse reward tasks. (Thesis). Keele University

Motion planning algorithms have seen a diverse set of approaches in a variety of disciplines. In the domain of artificial evolutionary systems, motion planning has been included in models to achieve sophisticated deliberate behaviours. These algorith... Read More about Evolving developmental, recurrent and convolutional neural networks for deliberate motion planning in sparse reward tasks.

The approach of the African National Congress to dealing with participatory spaces in post-apartheid South African local government (2020)
Thesis
Zantsi, L. K. (2020). The approach of the African National Congress to dealing with participatory spaces in post-apartheid South African local government. (Thesis). Keele University

This dissertation is an assessment of the African National Congress’s (ANC) approach to local participatory governance in post-apartheid South Africa. It examines public participation policies and the extent to which they have been implemented and se... Read More about The approach of the African National Congress to dealing with participatory spaces in post-apartheid South African local government.

Climate change and disappearing island states: deterritorialisation, sovereignty and statehood in international law (2020)
Thesis
Allen, E. L. (2020). Climate change and disappearing island states: deterritorialisation, sovereignty and statehood in international law. (Thesis). Keele University

At the present time, at least eight low-lying islands have been found to have disappeared as a result of climate change-induced rising sea levels and more seem likely to suffer the same fate in the future. Indeed, according to scientific estimates, i... Read More about Climate change and disappearing island states: deterritorialisation, sovereignty and statehood in international law.

Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis (2020)
Thesis
Kirkby, M. (2020). Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis. (Thesis). Keele University

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide that has been used extensively for the past half century as a topical antiseptic, due to its ability to effectively kill surface bacteria with minimal reports of resistance. However, bacteria... Read More about Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis.

Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa (2020)
Thesis
Beswick, L. E. M. (2020). Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa. (Thesis). Keele University

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterium, responsible for causing life threatening infections amongst fibrosis (CF) patients. Mucoid phenotypes of P. aeruginosa are characterised by overproduction of alginate, an extra-cel... Read More about Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa.

Long wave anti-plane motion in pre-stressed elastic laminates (2020)
Thesis
Mohammed Helmi, M. (2020). Long wave anti-plane motion in pre-stressed elastic laminates. (Thesis). Keele University

The propagation of long waves along pre-stressed compressible elastic laminates is considered, focusing on anti-plane shear type waves. Within this thesis we investigate the mechanical response of this type of motion for a class of compressible pre-s... Read More about Long wave anti-plane motion in pre-stressed elastic laminates.

Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo (2020)
Thesis
Turner, D. C. (2020). Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo. (Thesis). Keele University

Skeletal muscle (SkM) is an extremely abundant and mechano-sensitive tissue, demonstrating increases in mass and function following mechanical loading/resistance exercise (RE). Over the past 3 decades, there has been considerable progress in the deve... Read More about Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo.

Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies (2020)
Thesis
Morgan, R. L. (2020). Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies. (Thesis). Keele University

Cells secrete small membrane-bound extracellular vesicles (sEVs) called exosomes. These vesicles contain a mixture of protein, lipids, nucleic acids and saccharides (known collectively as cargo) that mediate therapeutic effects similar to their produ... Read More about Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies.

The epidemiology, prognosis and management of carpal tunnel syndrome in primary care (2020)
Thesis
Burton, C. L. (2020). The epidemiology, prognosis and management of carpal tunnel syndrome in primary care. (Thesis). Keele University

Carpal tunnel syndrome (CTS) is a compression neuropathy of the median nerve. Patients may experience discomfort in the hand and wrist, altered sensation and functional deficit. The management of mild to moderate CTS involves local corticosteroid inj... Read More about The epidemiology, prognosis and management of carpal tunnel syndrome in primary care.

Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum (2020)
Thesis
Famodimu, M. T. (2020). Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University

The emergence of P. falciparum resistant to current front-line artemisinin combination therapies underscores the urgent demand for new candidate molecules for a single exposure radical cure and prophylaxis drug. Developing a suitable candidate compon... Read More about Development and validation of a bioluminescence assay for high throughput screening of potent and rapidly cytocidal compounds against intraerythrocytic Plasmodium falciparum.

Somatosensory stimulation to improve lower-limb recovery after stroke (2020)
Thesis
Aries, A. M. (2020). Somatosensory stimulation to improve lower-limb recovery after stroke. (Thesis). Keele University

Introduction Increasing lower-limb sensation could improve walking post-stroke but evidence for this is limited. This thesis reports: 1) Review of published literature on somatosensory stimulation of the foot to enhance lower-limb function post-st... Read More about Somatosensory stimulation to improve lower-limb recovery after stroke.

Sediment deposition and preservation in Aeolian Systems: A comparison of contemporary and ancient ergs (2020)
Thesis
Cousins, D. P. (2020). Sediment deposition and preservation in Aeolian Systems: A comparison of contemporary and ancient ergs. (Thesis). Keele University

Ancient and contemporary aeolian systems have been subject of important conceptual advances in recent years, however, a disconnect exists between the complexities inherent at the depositional surface and subsequent controls on preservation. At the fu... Read More about Sediment deposition and preservation in Aeolian Systems: A comparison of contemporary and ancient ergs.

Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan (2020)
Journal Article
Shepherd, T. A., Ul-Haq, Z., Ul-Haq, M., Firaz Khan, M., Afridi, A., Dikomitis, L., …Farooq, S. (2020). Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan. BMJ Open, 10(6), https://doi.org/10.1136/bmjopen-2019-034709

Introduction: There is a significant treatment gap, with only a few community-based services for people with schizophrenia in Low- and Middle-Income countries. Poor treatment adherence in schizophrenia is associated with poorer health outcomes, suici... Read More about Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan.