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All Outputs (1748)

Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease (2020)
Thesis
Gómez Gálvez, Y. (2020). Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease. (Thesis). Keele University

The degeneration of dopaminergic neurons (DAn) in the midbrain substantia nigra pars compacta (SNpc) is a definitive feature of Parkinson's disease (PD). Although age has been established as one of the main risk factors, the role that ageing has in t... Read More about Effects of ageing on the vulnerability of the substantia nigra pars compacta dopaminergic neurons: implications in Parkinson’s disease.

Pain in community-dwelling people with dementia: a mixed methods study (2020)
Thesis
Bullock, L. (2020). Pain in community-dwelling people with dementia: a mixed methods study. (Thesis). Keele University

Introduction Dementia and pain are common in older adults. Clinical features of dementia such as communication difficulties may complicate the identification, assessment, and management of pain. This thesis therefore aimed to investigate pain ident... Read More about Pain in community-dwelling people with dementia: a mixed methods study.

An investigation into the detection of fraud during poultry egg production: a metabonomic approach using liquid chromatography - mass spectrometry (2020)
Thesis
Johnson, A. E. (2020). An investigation into the detection of fraud during poultry egg production: a metabonomic approach using liquid chromatography - mass spectrometry. (Thesis). Keele University

Food fraud is becoming an increasingly difficult challenge, with the ongoing global expansion of food supply chains. Previously developed methods have been successful in the detection of some instances of food fraud, however they struggle to detect m... Read More about An investigation into the detection of fraud during poultry egg production: a metabonomic approach using liquid chromatography - mass spectrometry.

A poet prepares: persona, process, and performance in the poetry of Anne Sexton (2020)
Thesis
Bailey, D. (2020). A poet prepares: persona, process, and performance in the poetry of Anne Sexton. (Thesis). Keele University

This thesis represents the first sustained examination of Sexton’s early and unpublished poetry, which was written between 1956 and 1960. Additionally, it also represents the first detailed scholarly attempt to discuss Sexton’s creative practice in r... Read More about A poet prepares: persona, process, and performance in the poetry of Anne Sexton.

Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes (2020)
Thesis
Osborn, A. H. (2020). Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes. (Thesis). Keele University

Fibrocyte degeneration in the cochlear lateral wall is one possible pathology of age-related metabolic hearing loss (presbyacusis). Fibrocytes play a role in potassium recycling and maintenance of the endocochlear potential (EP). It has been proposed... Read More about Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes.

Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation (2020)
Thesis
Berry, J. D. (2020). Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation. (Thesis). Keele University

Interprofessional education (IPE) has been proposed as a method of creating a collaborative practice ready workforce in healthcare. Postulated benefits of the technique include improving communication between professional groups, which in turn should... Read More about Collaborative behaviours and professional culture traits in real-time interprofessional clinical simulation.

Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study (2020)
Thesis
Machin, A. R. (2020). Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study. (Thesis). Keele University

Background Mood problems in people with rheumatoid arthritis (RA) are under-recognised and treated, contributing to increased mortality. Comorbid depression is associated with increased disease activity and reduced quality of life (QoL), though the... Read More about Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study.

Development of a novel doxorubicin delivery system for pancreatic cancer (2020)
Thesis
Al-Ameri, J. J. M. (2020). Development of a novel doxorubicin delivery system for pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is considered as the 4th most aggressive cancer in the Western world. There is a direct link between pancreatic cancer diagnosis and patient age with high occurrence of the disease happening in the 65-75-year age group. The majori... Read More about Development of a novel doxorubicin delivery system for pancreatic cancer.

Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. (2020)
Journal Article
Telling, & Everett. (2020). Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy. Angewandte Chemie International Edition, https://doi.org/10.1002/anie.202000239

A hallmark of Parkinson's disease is the death of neuromelanin-pigmented neurons, but the role of neuromelanin is unclear. The in situ characterization of neuromelanin remains dependent on detectable pigmentation, rather than direct quantification of... Read More about Label-Free Nanoimaging of Neuromelanin in the Brain by Soft X-ray Spectromicroscopy..

The experience of upper-limb dysfunction after stroke: a phenomenological study (2020)
Journal Article
Purton, J., Sim, J., & Hunter, S. (2020). The experience of upper-limb dysfunction after stroke: a phenomenological study. Disability and Rehabilitation, 43(23), 1 - 10. https://doi.org/10.1080/09638288.2020.1743775

Background: Stroke can bring about a profound disruption to people's lives, but what is less understood is the effect that specific dysfunctions can have. The aim of this study was to explore stroke survivors' experiences of upper-limb dysfunction ov... Read More about The experience of upper-limb dysfunction after stroke: a phenomenological study.

Government control and the value of cash: Evidence from listed firms in China (2020)
Journal Article
(2020). Government control and the value of cash: Evidence from listed firms in China. Review of Quantitative Finance and Accounting, https://doi.org/10.1007/s11156-020-00876-y

In this paper, we investigate the impact of government control on investors’ valuation of cash held by listed firms in China. We find strong and robust evidence that government control leads to a lower value of cash. Further evidence suggests that th... Read More about Government control and the value of cash: Evidence from listed firms in China.

Molecular crosstalk between non-SMN-related and SMN-related spinal muscular atrophy (2020)
Journal Article
Šoltić, D., & Fuller, H. (2020). Molecular crosstalk between non-SMN-related and SMN-related spinal muscular atrophy

Most cases of spinal muscular atrophy are caused by functional loss of the survival of motor neuron 1 (SMN1) gene, while less than 5% of cases are attributed to genes other than SMN. Mutations in LMNA, the lamin A/C encoding gene, cause an adult form... Read More about Molecular crosstalk between non-SMN-related and SMN-related spinal muscular atrophy.

Lenin’s 'Eastern policy' and communism in Turkey and Greece, 1918-1923 (2020)
Journal Article
Fouskas, V. K., & Gökay, B. (2020). Lenin’s 'Eastern policy' and communism in Turkey and Greece, 1918-1923. Journal of Balkan and Near Eastern Studies, 22(2), 210-221. https://doi.org/10.1080/19448953.2020.1746588

Examining Lenin's strategy towards colonial and semi-colonial periphery is crucial in understanding the way in which early Soviet policy was shaped and implemented towards the crucial conflict in Anatolia between Greece-Britain's proxy-and Turkish na... Read More about Lenin’s 'Eastern policy' and communism in Turkey and Greece, 1918-1923.

Expression of ALS-linked SOD1 mutation in motoneurons or myotubes induces differential effects on neuromuscular function in vitro (2020)
Journal Article
Benlefki, S., Sanchez-Vicente, A., Milla, V., Lucas, O., Soulard, C., Younes, R., …Hilaire, C. (2020). Expression of ALS-linked SOD1 mutation in motoneurons or myotubes induces differential effects on neuromuscular function in vitro. Neuroscience, 435, 33-43. https://doi.org/10.1016/j.neuroscience.2020.03.044

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that selectively affects upper and lower motoneurons. Dismantlement of the neuromuscular junction (NMJ) is an early pathological hallmark of the disease whose cellular origin re... Read More about Expression of ALS-linked SOD1 mutation in motoneurons or myotubes induces differential effects on neuromuscular function in vitro.

Implications of squirrelpox virus for successful red squirrel translocations within mainland UK (2020)
Journal Article
Sainsbury, A. W., Chantrey, J., Ewen, J. G., Gurnell, J., Hudson, P., Karesh, W. B., …Tompkins, D. M. (2020). Implications of squirrelpox virus for successful red squirrel translocations within mainland UK. Conservation Science and Practice, 2(6), Article e200. https://doi.org/10.1111/csp2.200

Remnant red squirrel populations in the UK mainland are threatened by squirrelpox viral disease and the reservoir of the squirrelpox virus, the invasive grey squirrel, is expanding its range. Until this threat can be effectively mitigated, there is a... Read More about Implications of squirrelpox virus for successful red squirrel translocations within mainland UK.

The Gaia-ESO Survey: detection and characterisation of single-line spectroscopic binaries (2020)
Journal Article
Merle, T., Van der Swaelmen, M., Van Eck, S., Jorissen, A., Jackson, R. J., Traven, G., …Prisinzano, L. (2020). The Gaia-ESO Survey: detection and characterisation of single-line spectroscopic binaries. Astronomy & Astrophysics, 635, https://doi.org/10.1051/0004-6361/201935819

Context. Multiple stellar systems play a fundamental role in the formation and evolution of stellar populations in galaxies. Recent and ongoing large ground-based multi-object spectroscopic surveys significantly increase the sample of spectroscopic b... Read More about The Gaia-ESO Survey: detection and characterisation of single-line spectroscopic binaries.