All Outputs (7)

Investigation of the blood proteome in response to spinal cord injury in rodent models (2021)
Journal Article
Hulme, C. H., Fuller, H. R., Riddell, J., Shirran, S. L., Botting, C. H., Osman, A., & Wright, K. T. (2022). Investigation of the blood proteome in response to spinal cord injury in rodent models. Spinal Cord, 60(4), 320-325. https://doi.org/10.1038/s41393-021-00692-8

STUDY DESIGN: Explanatory and Mechanistic Study OBJECTIVES: A better understanding of the ‘whole-body’ response following spinal cord injury (SCI) is needed to guide future research aimed at developing novel therapeutic interventions and identifying... Read More about Investigation of the blood proteome in response to spinal cord injury in rodent models.

Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. (2021)
Journal Article
McCarthy, H., Perry, J., Mennan, C., & Wright, K. (2021). Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. Cells, 1-16. https://doi.org/10.3390/cells10081999

Human umbilical cord (hUC)- or bone marrow (hBM)-derived mesenchymal stromal cells (MSCs) were evaluated as an allogeneic source of cells for cartilage repair. We aimed to determine if they could enhance healing of chondral defects with or without th... Read More about Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model..

An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. (2021)
Journal Article
Wright, K., Roberts, S., & Kuiper, J. (2021). An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, https://doi.org/10.3390/cells10081903

Chondrocyte-based cartilage repair strategies, such as articular chondrocyte implantation, are widely used, but few studies addressed the communication between native subchondral bone cells and the transplanted chondrocytes. An indirect co-culture mo... Read More about An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans..

The Management of Talar Osteochondral Lesions - Current Concepts (2021)
Journal Article
Lan, T., McCarthy, H., Hulme, C., Wright, K., & Makwana, N. (2021). The Management of Talar Osteochondral Lesions - Current Concepts. Journal of Arthroscopy and Joint Surgery, 231-237. https://doi.org/10.1016/j.jajs.2021.04.002

Osteochondral lesions of the talus (OLTs) are a common complication following trauma, involving both the articular cartilage and the underlying subchondral bone, with variable aetiologies and often presenting with non-specific symptoms. Diagnosis of... Read More about The Management of Talar Osteochondral Lesions - Current Concepts.

Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy (2021)
Journal Article
Hulme, C. H., Peffers, M. J., Harrington, G. M. B., Wilson, E., Perry, J., Roberts, S., …Wright, K. T. (2021). Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy. American Journal of Sports Medicine, 49(6), 1512-1523. https://doi.org/10.1177/0363546521995565

Background: Biomarkers are needed to predict clinical outcomes for microfracture and osteotomy surgeries to ensure patients can be better stratified to receive the most appropriate treatment. Purpose: To identify novel biomarker candidates and to... Read More about Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome After Microfracture or Osteotomy.

Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy (2021)
Journal Article
Hulme, & Wright, K. (2021). Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. Journal of Bone and Joint Surgery, British Volume, https://doi.org/10.1302/1358-992X.2021.2.008

Objectives The ability to predict which patients will improve following routine surgeries aimed at preventing the progression of osteoarthritis is needed to aid patients being stratified to receive the most appropriate treatment. This study aimed to... Read More about Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy.

Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury (2021)
Journal Article
Bahsoun, S., Kuiper, J., Hulme, C., Twigg, A., El Masri, W., Glass, C., …Wright, K. (2021). Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury. Scientific reports, 11, Article 4361. https://doi.org/10.1038/s41598-021-83211-2

A questionnaire was developed to evaluate patients' perspective on research aimed at improving functions and overcoming complications associated with spinal cord injury (SCI). The first three sections were based on published and validated assessment... Read More about Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury.