All Outputs (1797)

Training students in evidence-based software engineering and systematic reviews: a systematic review and empirical study (2021)
Journal Article
Pizard, S., Acerenza, F., Otegui, X., Moreno, S., Vallespir, D., & Kitchenham, B. (2021). Training students in evidence-based software engineering and systematic reviews: a systematic review and empirical study. Empirical Software Engineering, 26(3), Article 50. https://doi.org/10.1007/s10664-021-09953-9

Context Although influential in academia, evidence-based software engineering (EBSE) has had little impact on industry practice. We found that other disciplines have identified lack of training as a significant barrier to Evidence-Based Practice. Obj... Read More about Training students in evidence-based software engineering and systematic reviews: a systematic review and empirical study.

The VMC Survey – XLII. Near-infrared period–luminosity relations for RR Lyrae stars and the structure of the Large Magellanic Cloud (2021)
Journal Article
Cusano, F., Moretti, M. I., Clementini, G., Ripepi, V., Marconi, M., Cioni, M. L., …Van Loon, J. T. (2021). The VMC Survey – XLII. Near-infrared period–luminosity relations for RR Lyrae stars and the structure of the Large Magellanic Cloud. Monthly Notices of the Royal Astronomical Society, 504(1), 1 - 15. https://doi.org/10.1093/mnras/stab901

We present results from an analysis of ~29?000 RR Lyrae stars located in the Large Magellanic Cloud (LMC). For these objects, near-infrared time-series photometry from the VISTA survey of the Magellanic Clouds system (VMC) and optical data from the O... Read More about The VMC Survey – XLII. Near-infrared period–luminosity relations for RR Lyrae stars and the structure of the Large Magellanic Cloud.

Toward a More Nuanced Interpretation of Statistical Significance in Biomedical Research (2021)
Journal Article
Bajpai, R., & Chaturvedi, H. K. (2021). Toward a More Nuanced Interpretation of Statistical Significance in Biomedical Research. Asian Journal of Oncology, 07, 049-051. https://doi.org/10.1055/s-0041-1727066

Editorial
Statistical significance is the bedrock of evidence-based medicine, crucial for decision-making and framing biomedical science policies. The emergence of complex data in many disciplines, resulting from the analysis of large datasets, has... Read More about Toward a More Nuanced Interpretation of Statistical Significance in Biomedical Research.

Alexander Technique: an exploration of overcoming fear of falling in people aged 60 and over (2021)
Thesis
Tunnicliffe, E. (2021). Alexander Technique: an exploration of overcoming fear of falling in people aged 60 and over. (Thesis). Keele University

This thesis comprises a mixed-methods study aimed at exploring whether an Alexander Technique intervention would enable participants aged 60 years and over to improve their balance and movement, thereby increasing balance confidence and reducing fear... Read More about Alexander Technique: an exploration of overcoming fear of falling in people aged 60 and over.

Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee (2021)
Thesis
Hopkins, T. (2021). Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee. (Thesis). Keele University

Damage to the articular cartilage (AC) in the human knee, caused by physical trauma or degenerative disease, represents a common and complex clinical problem. AC has a very limited capacity for self-repair and, once damaged, rarely heals spontaneousl... Read More about Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee.

Practice Nurses' role extension and diagnostic work in long-term conditions: a qualitative metasynthesis and interview study (2021)
Thesis
Tan, V. A. (2021). Practice Nurses' role extension and diagnostic work in long-term conditions: a qualitative metasynthesis and interview study. (Thesis). Keele University

Background
Role extension is common in primary care in the UK, with assessment, diagnosis and management of some conditions by role extended nurses well established. Practice nurses (PNs) are now considered fundamental to the care of patients with... Read More about Practice Nurses' role extension and diagnostic work in long-term conditions: a qualitative metasynthesis and interview study.

Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex (2021)
Thesis
Pettitt, G. (2021). Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex. (Thesis). Keele University

Despite receiving the second largest dopaminergic projection from the ventral tegmental area (VTA) and having a pivotal role in conveying non-spatial information received from sensory cortices, the physiological functions of the lateral entorhinal co... Read More about Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex.

‘Social worker’ perceptions of organisational and professional changes to their work in Canada, England and South Africa (2021)
Thesis
Spolander, G. C. (2021). ‘Social worker’ perceptions of organisational and professional changes to their work in Canada, England and South Africa. (Thesis). Keele University

Growing global inequality, austerity and retrogressive social policy (Basu et al., 2017) provide the context for social work practice. The profession is committed to empowering people and addressing social justice, inequality and social cohesion but... Read More about ‘Social worker’ perceptions of organisational and professional changes to their work in Canada, England and South Africa.

1. The revolt of the dolls: a novel and 2. The revolt of the dolls and other small rebellions: a critical introduction to the fairy-tales of Sophie von Baudissin (2021)
Thesis
Sampson, E. S. (2021). 1. The revolt of the dolls: a novel and 2. The revolt of the dolls and other small rebellions: a critical introduction to the fairy-tales of Sophie von Baudissin. (Thesis). Keele University

The German nineteenth-century fairy-tale has long been, and remains, largely synonymous with the tales of the Brothers Grimm, particularly in the wider public consciousness. While there is some awareness among the general public of other, contemporan... Read More about 1. The revolt of the dolls: a novel and 2. The revolt of the dolls and other small rebellions: a critical introduction to the fairy-tales of Sophie von Baudissin.

Balancing value and effort: a classic grounded theory of frontline police practice (2021)
Thesis
Ash, D. P. (2021). Balancing value and effort: a classic grounded theory of frontline police practice. (Thesis). Keele University

This thesis seeks to explain the behaviour of frontline police officers engaged in incident work. Policymakers try to improve police legitimacy by changing how individual police officers interact with the public at police incidents. However, police p... Read More about Balancing value and effort: a classic grounded theory of frontline police practice.

Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models (2021)
Thesis
Green, E. L. (2021). Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models. (Thesis). Keele University

Parkinson’s disease (PD) is characterised by motor symptoms caused by degeneration of dopaminergic neurons in the substantia nigra. The cause remains elusive and current treatments cannot halt or reverse progression. This thesis explores the effects... Read More about Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models.

Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex (2021)
Thesis
Wells, T. R. (2021). Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex. (Thesis). Keele University

The entorhinal cortex serves as the interface region between allocortical input and the hippocampus, with current theories suggesting that the region is involved in memory encoding, with dopamine serving as a “motivational currency” provided to memor... Read More about Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex.

Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes (2021)
Thesis
Bhunia, S. (2021). Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes. (Thesis). Keele University

The fetal membrane surrounds and supports the developing fetus during the pregnancy. The cellular structure of the fetal membrane and the proteins synthesized by the cells of amniotic and chorionic membranes, maintain the mechanical integrity of the... Read More about Investigation of correlation of biochemical marker expression and mechanical properties of preterm membranes.

A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors (2021)
Thesis
Odingo, M. O. (2021). A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors. (Thesis). Keele University

Introduction
A new class of lipid lowering agent Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors (PCSK9) was launched in 2015 for the treatment of heterozygous familial hypercholesterolemia (HeFH) in combination with statin therapy. There a... Read More about A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors.

Evaluation of surgical outcomes using administrative hospital data (2021)
Thesis
El-Dhuwaib, Y. (2021). Evaluation of surgical outcomes using administrative hospital data. (Thesis). Keele University

Hospital Episode Statistics (HES) is the main hospital administrative dataset in England. Since the early 1990s HES has been used for research. The aim of the thesis is to evaluate the use of HES data to measure surgical outcomes.

Objectives:
1.... Read More about Evaluation of surgical outcomes using administrative hospital data.

Physical activity in people with osteoarthritis and comorbidity: a multi-method study (2021)
Thesis
McKevitt, S. (2021). Physical activity in people with osteoarthritis and comorbidity: a multi-method study. (Thesis). Keele University

Osteoarthritis (OA) is common and associated with one of the highest comorbidity rates. OA clinical guidelines recommend physical activity (PA) as core treatment, irrespective of comorbidity. However, no current synthesis of the effectiveness of PA f... Read More about Physical activity in people with osteoarthritis and comorbidity: a multi-method study.

The meaning of life: a defence of the question’s legitimacy and routes towards ultimate meaning (2021)
Thesis
Fox, J. (2021). The meaning of life: a defence of the question’s legitimacy and routes towards ultimate meaning. (Thesis). Keele University

This dissertation establishes and defends three positions: (1) The question ‘What is the meaning of life?’ is a request for a global-metaphysical explanation for life and existence that narrates across those elements of most existential import to hum... Read More about The meaning of life: a defence of the question’s legitimacy and routes towards ultimate meaning.

Preparation and structural studies of halogen bonded co-crystals (2021)
Thesis
Mahmood, A. S. M. (2021). Preparation and structural studies of halogen bonded co-crystals. (Thesis). Keele University

The project investigates the reactions of selected aromatic nitrogen compounds with selected di- and interhalogens in order to obtain crystalline N···I halogen-bonded complexes according to the equation:
A + B ? AB

where reactant A is a pyridine... Read More about Preparation and structural studies of halogen bonded co-crystals.

The formation of a cross-town Multi-Academy Trust: A case of policy enactment in the local organisation of education (2021)
Thesis
Hay, A. L. (2021). The formation of a cross-town Multi-Academy Trust: A case of policy enactment in the local organisation of education. (Thesis). Keele University

This research investigates two high schools and one middle school in the grip of a seismic policy change as they set aside generations of rivalry to work together as a newly formed Multi-Academy Trust (MAT). It adopts an insider case study approach;... Read More about The formation of a cross-town Multi-Academy Trust: A case of policy enactment in the local organisation of education.

4:23 PM, Relaxant (2021)
Thesis
Bolger, L. S. A. (2021). 4:23 PM, Relaxant. (Thesis). Keele University

The practical component of this thesis is a collection of poems entitled 4:23 PM, Relaxant, which consists of an original collection of verse written mainly in the confessional tradition. The collection addresses a number of themes including family a... Read More about 4:23 PM, Relaxant.