All Outputs (536)

Measles and Pertussis outbreaks in England and Wales: a time-series analysis (2024)
Journal Article
Shepherd, T., & Mallen, C. (in press). Measles and Pertussis outbreaks in England and Wales: a time-series analysis. NIHR Open Research, 4, 56. https://doi.org/10.3310/nihropenres.13607.1

Background
Vaccine coverage for common infectious diseases such as Measles and Pertussis (also known as whooping cough) have been declining in England and Wales since 2014. Consequently, significant increases in Measles and Pertussis cases are obser... Read More about Measles and Pertussis outbreaks in England and Wales: a time-series analysis.

Association of air pollution from a landfill site with primary care consultation (2024)
Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., …van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.

Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Singh Sokhal, B., Prasanna Kumar Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, https://doi.org/10.3310/nihropenres.13623.1

Introduction
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence is rising, and studies have reported potential sex and race disparities in patient outcomes. D... Read More about Temporal Trends in Parkinson’s Disease Related Mortality from 1999-2020: A National Analysis [version 1; peer review: awaiting peer review].

2235 National Trends in motor neurone disease-associated mortality from 1999–2020 (2024)
Journal Article
Imantalab, D., Sokhal, B., Menon, S., Kara, S., Muller, S., & Mallen, C. (2024). 2235 National Trends in motor neurone disease-associated mortality from 1999–2020. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.074

Introduction Motor Neurone Disease (MND) is a neurodegenerative condition affecting the spinal cord and brainstem, commonly associated with a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United S... Read More about 2235 National Trends in motor neurone disease-associated mortality from 1999–2020.

2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients (2024)
Journal Article
Sokhal, B., Matetić, A., Protheroe, J., Helliwell, T., Myint, P., Paul, T., …Mamas, M. (2024). 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.051

Introduction Data are limited on whether the causes of Emergency Department (ED) attendance and clinical outcomes vary by frailty status. Methods Using data from the Nationwide Emergency Department Sample, all ED attendances from 2016 to 2018 were st... Read More about 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients.

2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study (2024)
Journal Article
Sokhal, B., Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study. Age and ageing, 53(Supplement_3), iii19. https://doi.org/10.1093/ageing/afae139.073

Introduction Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence of PD is increasing and the literature demonstrates potential sex and race disparities in patie... Read More about 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study.

Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study. (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study. The Lancet Rheumatology, 6(9), e615-e624. https://doi.org/10.1016/S2665-9913%2824%2900128-0

People with immune-mediated inflammatory disease are at increased risk of pneumococcal pneumonia. The effectiveness of pneumococcal vaccination in people with immune-mediated inflammatory diseases has not been evaluated. We investigated the effective... Read More about Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study..

Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection (2024)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S. A., Jinks, C., Buttery, A., Ashworth, J., …Dikomitis, L. (2024). Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection. British Journal of Pain, https://doi.org/10.1177/20494637241254098

Introduction
Understanding patients’ experiences is important when developing interventions for people living with persistent pain. Interviews and focus groups are frequently used to capture beliefs, views, and perspectives. These methods often requ... Read More about Hearing the patient voice for persistent pain intervention development: recommendations for using a bespoke online discussion forum for qualitative data collection.

Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection (2024)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S., Jinks, C., Buttery, A., Ashworth, J., …Dikomitis, L. (2024). Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection. British Journal of Pain, https://doi.org/10.1177/204946372412540

Introduction Understanding patients’ experiences is important when developing interventions for people living with persistent pain. Interviews and focus groups are frequently used to capture beliefs, views, and perspectives. These methods often requi... Read More about Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection.

The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica (2024)
Journal Article
Scott, I. C., Bajpai, R., Hider, S. L., Helliwell, T., Mallen, C. D., & Muller, S. (in press). The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica. Rheumatology Advances in Practice, 8(3), Article rkae081. https://doi.org/10.1093/rap/rkae081

Objective
To examine the association between obesity and patient-reported outcomes measures (PROMs) in a primary care-based cohort of people with polymyalgia rheumatica (PMR).

Methods
The PMR Cohort Study recruited people with incident PMR from... Read More about The Relationship Between Obesity and Patient-Reported Outcome Measures in People with Polymyalgia Rheumatica.

Relationship between research activity and general practice performance: cross sectional and longitudinal analyses. (2024)
Journal Article
Gibson, J., Kontopantelis, E., Sutton, M., Boaz, A., Little, P., Mallen, C. D., …Bower, P. (in press). Relationship between research activity and general practice performance: cross sectional and longitudinal analyses. British Journal of General Practice (BJGP), BJGP.2024.0111. https://doi.org/10.3399/BJGP.2024.0111

Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that these relation... Read More about Relationship between research activity and general practice performance: cross sectional and longitudinal analyses..

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary
Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

AB0105 ‘..THERE’S TOO MUCH TO PUT IN A LEAFLET’: A QUALITATIVE EXPLORATION OF STAKEHOLDER VIEWS OF LIFESTYLE INTERVENTIONS FOR GOUT (2024)
Presentation / Conference
Watson, L., Cornwall, N., Jinks, C., Bradbury, K., Goff, L., Little, P., …Roddy, E. (2024, June). AB0105 ‘..THERE’S TOO MUCH TO PUT IN A LEAFLET’: A QUALITATIVE EXPLORATION OF STAKEHOLDER VIEWS OF LIFESTYLE INTERVENTIONS FOR GOUT. Paper presented at EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria, Vienna

AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM (2024)
Presentation / Conference
Scott, I., Daud, N., Bailey, J., Twohig, H., Hider, S., Mallen, C., …Muller, S. (2024, June). AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM. Paper presented at EULAR 2024 European Congress of Rheumatology, 12-15 June. Vienna, Austria, Vienna

associate with an increased risk of fractures. The potential for confounding inherent to non-randomised studies of interventions, however, alongside the conflicting findings of these studies (with some reporting an increased risk [1] and others no re... Read More about AB0228 GABAPENTINOID USE AND THE RISK OF FRACTURES IN PEOPLE WITH INFLAMMATORY ARTHRITIS: NESTED CASE-CONTROL STUDY IN THE CLINICAL PRACTICE RESEARCH DATALINK (CPRD) AURUM.

44 Impact of the danish comorbidity index for acute myocardial infarction score on 30-day unplanned readmission rates and causes in hospitalised patients with acute coronary syndrome (2024)
Presentation / Conference
Sokhal, B. S., Matetić, A., Marshall, M., Twohig, H., Shepherd, T., Mallen, C., & Mamas, M. (2024, June). 44 Impact of the danish comorbidity index for acute myocardial infarction score on 30-day unplanned readmission rates and causes in hospitalised patients with acute coronary syndrome. Paper presented at British Cardiovascular Society Annual Conference, ‘Back to the patient’, 3–5 June 2024, Manchester

Introduction This study aimed to investigate the association of the DANish CoMorbidity Index for Acute Myocardial Infarction (DANCAMI) score with the 30-day unplanned readmission rates and causes and in acute coronary syndrome (ACS) patients.

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective: To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventi... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

2023 EULAR classification criteria for hand osteoarthritis. (2024)
Journal Article
Haugen, I. K., Felson, D. T., Abhishek, A., Berenbaum, F., Bierma-Zeinstra, S., Dziedzic, K. S., …Kloppenburg, M. (in press). 2023 EULAR classification criteria for hand osteoarthritis. Annals of the Rheumatic Diseases, https://doi.org/10.1136/ard-2023-225073

The objective of this study is to develop classification criteria for overall hand osteoarthritis (OA), interphalangeal OA and thumb base OA based on self-reported data and radiographic features. The classification criteria sets were developed in thr... Read More about 2023 EULAR classification criteria for hand osteoarthritis..

P187 Fatigue in people with polymyalgia rheumatica: a key unmet need? (2024)
Presentation / Conference
Muller, S., Belcher, J., Hider, S., Helliwell, T., & Mallen, C. D. (2024, April). P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. Glucocorticoids treatment generally focusses on reducing pain and stiffness, but there are other... Read More about P187 Fatigue in people with polymyalgia rheumatica: a key unmet need?.

P021 Uptake, safety, and effectiveness of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide study using data from the Clinical Practice Research Datalink (2024)
Presentation / Conference
Nakafero, G., Grainge, M. J., Mallen, C. D., Card, T., Nguyen Van-Tam, J. S., & Abhishek, A. (2024, April). P021 Uptake, safety, and effectiveness of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide study using data from the Clinical Practice Research Datalink. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims The safety and effectiveness of pneumococcal vaccine in people with immune mediated inflammatory diseases (IMIDs) is not known, which may contribute to suboptimal uptake. We investigated UK wide pneumococcal vaccine uptake in adults w... Read More about P021 Uptake, safety, and effectiveness of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide study using data from the Clinical Practice Research Datalink.

P080 Supporting shared decision-making about osteoporosis medicines: Combining multiple methods to develop the prototype iFraP intervention (2024)
Presentation / Conference
Bullock, L., Fleming, J., Clark, E. M., Leyland, S., Thomas, S., Gidlow, C., …Paskins, Z. (2024, April). P080 Supporting shared decision-making about osteoporosis medicines: Combining multiple methods to develop the prototype iFraP intervention. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Shared decision-making (SDM) is a joint process in which a person and healthcare professional work together to reach decisions about care. The iFraP (Improving uptake of Fracture Prevention drug treatments) intervention comprises comp... Read More about P080 Supporting shared decision-making about osteoporosis medicines: Combining multiple methods to develop the prototype iFraP intervention.