All Outputs (15)

A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury (2024)
Journal Article
Kalsoum, R., Minns Lowe, C. J., Gilbert, S., McCaskie, A. W., Snow, M., Wright, K., …Watt, F. E. (in press). A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury. Bone & Joint Research, 13(9), 513-524. https://doi.org/10.1302/2046-3758.139.BJR-2024-0109

Aims
To explore key stakeholder views around feasibility and acceptability of trials seeking to prevent post-traumatic osteoarthritis (PTOA) following knee injury, and provide guidance for next steps in PTOA trial design.

Methods
Healthcare prof... Read More about A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.

Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome (2024)
Journal Article
Tierney, L., Kuiper, J. H., Roberts, S., Snow, M., Williams, M., Harrington, M. B., …Wright, K. T. (in press). Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome. Knee Surgery, Sports Traumatology, Arthroscopy, https://doi.org/10.1002/ksa.12433

Purpose: To investigate patient demographic, injury and surgery/treatment‐associated factors that can influence the patient‐reported outcome (Lysholm score), following autologous chondrocyte implantation (ACI) in a large, ‘real‐world’, nonuniform, pr... Read More about Lower cell number, lateral defect location and milder grade are associated with improved autologous chondrocyte implantation outcome.

284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. (2024)
Presentation / Conference
Kuiper, J. H., Dewan, V., Tierney, L., Roberts, S., Harrison, P., Gallacher, P., …Wright, K. T. (2024, April). 284 Lower Cell Number Implanted is Consistently Associated with Improved Functional Outcome Post-Autologous Chondrocyte Implantation in Longitudinal Multilevel Modelling Analyses. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

344 CO-DESIGNING ACCEPTABLE, FEASIBLE TRIALS TO TEST DRUGS TARGETING PREVENTION OF POST-TRAUMATIC OSTEOARTHRITIS AFTER KNEE INJURY: PIPEDREAM OR REALITY? (2024)
Presentation / Conference
Kalsoum, R., Brewer, G., Lowe, C. M., Papadaki, A., Nigrelli, L., Gilbert, S., …Watt, F. E. (2024, April). 344 CO-DESIGNING ACCEPTABLE, FEASIBLE TRIALS TO TEST DRUGS TARGETING PREVENTION OF POST-TRAUMATIC OSTEOARTHRITIS AFTER KNEE INJURY: PIPEDREAM OR REALITY?. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

504 IS SPECT/CT A USEFUL IMAGING TOOL FOR THE IDENTIFICATION OF KNEE CARTILAGE LESIONS: A SYSTEMATIC REVIEW (2024)
Presentation / Conference
Rix, L., Tushingham, S., Wright, K. T., & Snow, M. (2024, April). 504 IS SPECT/CT A USEFUL IMAGING TOOL FOR THE IDENTIFICATION OF KNEE CARTILAGE LESIONS: A SYSTEMATIC REVIEW. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

No correlation exists Between Tibial And Femoral Based Measurements Of Patella Alta In A Population with chronic patellofemoral pain or instability undergoing patella distalisation (2024)
Journal Article
Snow, M., Singh, N., Rix, L., & Haikal, M. (2024). No correlation exists Between Tibial And Femoral Based Measurements Of Patella Alta In A Population with chronic patellofemoral pain or instability undergoing patella distalisation. Arthroscopy: The Journal of Arthroscopy and Related Surgery, https://doi.org/10.1016/j.arthro.2024.01.036

Purpose
To investigate if Patellotrochlear index (PTI) predicts patella alta as determined by tibial based methods of Insall Salvati (IS) and Caton Deschamp (CD) in a pathological population (with patellofemoral p... Read More about No correlation exists Between Tibial And Femoral Based Measurements Of Patella Alta In A Population with chronic patellofemoral pain or instability undergoing patella distalisation.

EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW (2023)
Journal Article
Rix, L., Tushingham, S., Wright, K., & Snow, M. (2023). EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW. Orthopaedic Proceedings, 105-B(SUPP_16), 45-45. https://doi.org/10.1302/1358-992x.2023.16.045

AbstractObjectiveA common orthopaedic pain found in a wide spectrum of individuals, from young and active to the elderly is anterior knee pain (AKP). It is a multifactorial disorder which is thought to occur through muscular imbalance, overuse, traum... Read More about EVALUATING THE UTILITY OF SPECT/CT FOR THE IDENTIFICATION OF CARTILAGE LESIONS: A SYSTEMATIC REVIEW.

A novel injectable hydrogel-based drug delivery system for the repair of cartilage defects (2023)
Presentation / Conference
Atwal, A., Davoodi, P., Forsyth, N. R., & Snow, M. (2023, March). A novel injectable hydrogel-based drug delivery system for the repair of cartilage defects. Presented at TERMIS 2023 – European Chapter, Manchester Central Conference Centre Manchester, UK

Fabrication of an injectable hydrogel with controllable in situ pore formation for the repair of chondral lesions (2023)
Presentation / Conference
Atwal, A., Davoodi, P., Forsyth, N. R., & Snow, M. (2023, March). Fabrication of an injectable hydrogel with controllable in situ pore formation for the repair of chondral lesions. Poster presented at TERMIS 2023 – European Chapter, Manchester Central Conference Centre Manchester, UK

Assessing Allogeneic Chondroprogenitor Manufacture Under Good Manufacturing Practice (GMP) Serum Free And Xeno-Free Conditions. (2023)
Conference Proceeding
McCarthy, Hulme, Perry, & Snow. (2023). Assessing Allogeneic Chondroprogenitor Manufacture Under Good Manufacturing Practice (GMP) Serum Free And Xeno-Free Conditions. . https://doi.org/10.1016/j.joca.2023.01.223

A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee (2023)
Journal Article
Snow, M., Middleton, L., Mehta, S., Roberts, A., Gray, R., Richardson, J., …O’Brien, S. (2023). A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee. American Journal of Sports Medicine, 51(2), 367-378. https://doi.org/10.1177/03635465221141907

BACKGROUND: There are limited randomized controlled trials with long-term outcomes comparing autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management within the knee. PURPOSE: To determine at 5 years after s... Read More about A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee.

Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial (2022)
Journal Article
Beard, D. J., Davies, L., Cook, J. A., Stokes, J., Leal, J., Fletcher, H., …Mohammed, A. (2022). Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial. The Lancet, 400, 605 - 615. https://doi.org/10.1016/S0140-6736%2822%2901424-6

Background
Anterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients w... Read More about Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial.

Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom (2022)
Journal Article
Javanbakht, M., Mashayekhi, A., Carlson, A., Moloney, E., Snow, M., Murray, J., & Spalding, T. (2022). Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom. PharmacoEconomics, 6(5), 681-696. https://doi.org/10.1007/s41669-022-00336-4

Background The most common intra-articular knee injury is a meniscal tear, which commonly occurs secondary to trauma following twisting or hyperflexion. Treatment options for meniscal tears can either be surgical or non-surgical, and range from rest,... Read More about Cost-Effectiveness Analysis of a Medial Meniscus Replacement Prosthesis for the Treatment of Patients with Medial Compartment Pain in the United Kingdom.

Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair? (2021)
Journal Article
Amit, P., Kuiper, J. H., James, S., & Snow, M. (2021). Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?. Journal of Shoulder and Elbow Surgery, 2465-2474. https://doi.org/10.1016/j.jse.2021.05.014

PURPOSE: Hyperlipidemia is linked to poor tendon to bone healing and progression of fatty infiltration after rotator cuff repair. Statins effectively treat hyperlipidemia, but it is unknown if they have any potential detrimental effects following rot... Read More about Does statin-treated hyperlipidemia affect rotator cuff healing or muscle fatty infiltration after rotator cuff repair?.

An In Vitro Comparison of the Incorporation, Growth, and Chondrogenic Potential of Human Bone Marrow versus Adipose Tissue Mesenchymal Stem Cells in Clinically Relevant Cell Scaffolds Used for Cartilage Repair. (2015)
Journal Article
Kohli, N., Wright, K. T., Sammons, R. L., Jeys, L., Snow, M., & Johnson, W. E. (2015). An In Vitro Comparison of the Incorporation, Growth, and Chondrogenic Potential of Human Bone Marrow versus Adipose Tissue Mesenchymal Stem Cells in Clinically Relevant Cell Scaffolds Used for Cartilage Repair. Cartilage, 6(4), 252 -263. https://doi.org/10.1177/1947603515589650

AIM: To compare the incorporation, growth, and chondrogenic potential of bone marrow (BM) and adipose tissue (AT) mesenchymal stem cells (MSCs) in scaffolds used for cartilage repair. METHODS: Human BM and AT MSCs were isolated, culture expanded, and... Read More about An In Vitro Comparison of the Incorporation, Growth, and Chondrogenic Potential of Human Bone Marrow versus Adipose Tissue Mesenchymal Stem Cells in Clinically Relevant Cell Scaffolds Used for Cartilage Repair..