All Outputs (10)

Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria (2023)
Journal Article

Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication of malaria. HRPII has been sh... Read More about Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria.

Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis (2020)
Journal Article

The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here that macrophage proliferation is a s... Read More about Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis.

The perplexing PEXEL protein secretory pathway (2018)
Journal Article

Plasmodium parasites possess a unique PEXEL sorting pathway to deliver secretory proteins into the host cells in which they reside. A new study shows the existence of independent sorting/entry complexes to detect and deliver PEXEL proteins into the p... Read More about The perplexing PEXEL protein secretory pathway.

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite (2018)
Journal Article

Parasite egress from infected erythrocytes and invasion of new red blood cells are essential processes for the exponential asexual replication of the malaria parasite. These two tightly coordinated events take place in less than a minute and are in p... Read More about Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.

Evaluation of analogues of furan-amidines as inhibitors of NQO2 (2018)
Journal Article

Inhibitors of the enzyme NQO2 (NRH: quinone oxidoreductase 2) are of potential use in cancer chemotherapy and malaria. We have previously reported that non-symmetrical furan amidines are potent inhibitors of NQO2 and here novel analogues are evaluate... Read More about Evaluation of analogues of furan-amidines as inhibitors of NQO2.

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition (2018)
Journal Article

Owing to the prevalence of tumor-associated macrophages (TAMs) in cancer and their unique influence upon disease progression and malignancy, macrophage-targeted interventions have attracted notable attention in cancer immunotherapy. However, tractabl... Read More about Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion (2017)
Journal Article

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied e... Read More about Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region (2015)
Journal Article

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essent... Read More about Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation (2009)
Journal Article

Background: Post-transcriptional control of gene expression is suspected to play an important role in malaria parasites. In yeast and metazoans, part of the stress response is mediated through phosphorylation of eukaryotic translation initiation fact... Read More about PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation.

Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus (2009)
Journal Article

The Plasmodium falciparum genome encodes a single calpain. By generating P. falciparum clones expressing C-terminally tagged calpain, we localized this protein to the nucleolus. Pf_calpain possesses an unusual and long N-terminal domain in which we i... Read More about Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus.