All Outputs (37)

Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy (2023)
Journal Article

The management of cancer patients has markedly improved with the advent of personalised medicine where treatments are given based on tumour antigen expression amongst other. Within this remit, liquid biopsies will no doubt improve this personalised c... Read More about Fourier Transform Infrared microspectroscopy identifies single cancer cells in blood. A feasibility study towards liquid biopsy.

Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens. (2023)
Journal Article

Dried plant specimens stored in herbaria are an untapped treasure chest of information on environmental conditions, plant evolution and change over many hundreds of years. Owing to their delicate nature and irreplaceability, there is limited access f... Read More about Fourier transform infrared spectroscopy as a non-destructive method for analysing herbarium specimens..

Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells. (2023)
Journal Article

It is well known that infrared microscopy of micrometer sized samples suffers from strong scattering distortions, attributed to Mie scattering. The state-of-the-art preprocessing technique for modelling and removing Mie scattering features from infra... Read More about Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells..

Detection of lipid efflux from foam cell models using a label-free infrared method (2022)
Journal Article

Cardiovascular diseases are still among the leading causes of mortality and morbidity worldwide. The build-up of fatty plaques in the arteries, leading to atherosclerosis, is the most common cause of cardiovascular diseases. The central player in ath... Read More about Detection of lipid efflux from foam cell models using a label-free infrared method.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article

Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improves key h... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.

Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases (2021)
Journal Article

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the... Read More about Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases.

Optical Photothermal Infrared Microspectroscopy Discriminates for the First Time Different Types of Lung Cells on Histopathology Glass Slides. (2021)
Journal Article

The debate of whether a glass substrate can be used in Fourier transform infrared spectroscopy is strongly linked to its potential clinical application. Histopathology glass slides of 1 mm thickness absorb the mid-IR spectrum in the rich fingerprint... Read More about Optical Photothermal Infrared Microspectroscopy Discriminates for the First Time Different Types of Lung Cells on Histopathology Glass Slides..

Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer (2021)
Book Chapter

The provision of information on radiotherapy (RT) planning and delivery for patient with cancer is a vital issue in improving not only patients’ satisfaction but also patients’ compliance to treatment. In the present study, patients with prostate can... Read More about Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer.

Optimisation of sample preparation using glass slides for spectral pathology (2020)
Journal Article

The clinical translation of Fourier Transform Infrared (FTIR) microspectroscopy in pathology will require bringing this technique as close as possible to standard practice in pathology departments. An important step is sample preparation for both FTI... Read More about Optimisation of sample preparation using glass slides for spectral pathology.

Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology? (2019)
Journal Article

The rising incidence of cancer worldwide is causing an increase in the workload in pathology departments. This, coupled with advanced analysis methodologies, supports a developing need for techniques that could identify the presence of cancer cells i... Read More about Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology?.

Striking lung cancer response to self-administration of cannabidiol: a case report and literature review (2019)
Journal Article

In spite of new drugs, lung cancer is associated with a very poor prognosis. Whilst targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow up. Thus, new drugs or re-e... Read More about Striking lung cancer response to self-administration of cannabidiol: a case report and literature review.

Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology (2018)
Journal Article

Over the last few years, great effort has been placed on developing Fourier Transform Infrared (FTIR) microspectroscopy as a tool to help in the histopathological diagnosis of cancer. The ever increasing workload in pathology departments is calling f... Read More about Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology.

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model. (2018)
Journal Article

Isolated and monolayer expanded chondrocytes are not the ideal cell form to produce a cartilage matrix. In articular cartilage, each chondrocyte is surrounded by a 2-4 µm thick collagen VI-rich pericellular matrix (PCM) forming a chondron. Freshly ex... Read More about Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model..

Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. (2018)
Journal Article

Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolution... Read More about Clinical applications of infrared and Raman spectroscopy: state of play and future challenges..

Correction: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. (2018)
Journal Article

Correction for 'Clinical applications of infrared and Raman spectroscopy: state of play and future challenges' by Matthew J. Baker, et al., Analyst, 2018, DOI: 10.1039/c7an01871a.

Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer (2017)
Conference Proceeding

Lung cancer is a widespread disease and it is well understood that systematic, non-invasive and early detection of this progressive and life-threatening disorder is of vital importance for patient outcomes. In this work we present a convergence of fa... Read More about Artificial Neural Network Analysis of Volatile Organic Compounds for the detection of lung cancer.

Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace (2017)
Journal Article

Rationale Peroxidation of lipids in cellular membranes results in the release of volatile organic compounds (VOCs), including saturated aldehydes. The real-time quantification of trace VOCs produced by cancer cells during peroxidative stress present... Read More about Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace.

Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning (2016)
Journal Article

Over the last few years, both synchrotron-based FTIR (S-FTIR) and Raman microspectroscopies have helped to better understand the effects of drugs on cancer cells. However, cancer is a mixture of cells with different sensitivity/resistance to drugs. F... Read More about Effects of nilotinib on leukaemia cells using vibrational microspectroscopy and cell cloning.

Clinical Spectroscopy: general discussion (2016)
Journal Article

Biofluids and other techniques: general discussion (2016)
Journal Article