All Outputs (27)

Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study (2024)
Journal Article

Objectives Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact with colchicine, increasing the r... Read More about Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study.

Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink (2023)
Journal Article

Objectives: To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout. Methods: We conducted two matched retrospective cohort studies in... Read More about Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.

Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study (2023)
Journal Article

BACKGROUND: Most adults presenting in primary care with chest pain symptoms will not receive a diagnosis ("unattributed" chest pain) but are at increased risk of cardiovascular events. AIM: To assess within patients with unattributed chest pain, risk... Read More about Determining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study.

Prediction of cardiovascular disease in patients with unattributed chest pain in UK primary care (2022)
Conference Proceeding

P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies (2022)
Journal Article

Abstract Background/Aims Initiating urate-lowering therapy for gout commonly triggers a gout flare and hence co-prescription of colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis is recommended. However, little is known about the... Read More about P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies.

Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study (2022)
Journal Article

Background Most adults presenting with chest pain will not receive a diagnosis and be recorded with unattributed chest pain. The objective was to assess if they have increased risk of cardiovascular disease compared with those with noncoronary chest... Read More about Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study.

Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study (2021)
Journal Article

Background Patients presenting to primary care with chest pain are often not given a cause. Patients with such unattributed chest pain have an increased risk of future cardiovascular disease (CVD) compared to patients with diagnosed non-coronary che... Read More about Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study.

Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy (2021)
Journal Article

Objectives: The present study sought to examine national-level differences in management strategies and outcomes in patients with autoimmune rheumatic disease (AIRD) with acute myocardial infarction (AMI) between 2004 and 2014. Methods: All AMI hos... Read More about Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction (2020)
Journal Article

Objectives Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction. (2020)
Journal Article

OBJECTIVES: Despite many shared risk factors and pathophysiological pathways, the risk of ischaemic heart disease (IHD) and myocardial infarction (MI) in interstitial lung disease (ILD) remains poorly understood. This lack of data could be preventing... Read More about Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction..

The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure (2020)
Journal Article

Background: Little is known about frailty amongst patients hospitalized with heart failure (HF) on a national level. Methods: We conducted a retrospective cohort study of patients admitted to hospital for HF in the United States. We examined how... Read More about The Hospital Frailty Risk Score and its association with in-hospital mortality, cost, length of stay and discharge location in patients with heart failure.

Early Unplanned Readmissions after Admission to Hospital with Heart Failure (2019)
Journal Article

Hospital readmissions remain a continued challenge in the care of patients with heart failure (HF). This study aims to examine the rates, temporal trends, predictors and causes of 30-day unplanned readmissions after admission with HF. Patients hospit... Read More about Early Unplanned Readmissions after Admission to Hospital with Heart Failure.

Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy. (2019)
Journal Article

BACKGROUND: Systemic inflammatory diseases have been associated with increased risk of venous thromboembolism. We aimed to quantify the risk of venous thromboembolism in patients with gout, the most common inflammatory arthritis, and to assess how di... Read More about Venous thromboembolism in patients with gout and the impact of hospital admission, disease duration and urate-lowering therapy..

Multisite pain and self-reported falls in older people: systematic review and meta-analysis. (2019)
Journal Article

BACKGROUND: Multisite pain and falls are common in older people, and isolated studies have identified multisite pain as a potential falls risk factor. This study aims to synthesise published literature to further explore the relationship between mu... Read More about Multisite pain and self-reported falls in older people: systematic review and meta-analysis..

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study (2018)
Presentation / Conference

Background/Purpose: Evidence is conflicting concerning dementia risk in gout patients, with hyperuricaemia proposed to exert a neuroprotective effect. Serum urate (sUA) targets guiding urate-lowering therapies (ULT) are poorly evidenced-based and th... Read More about Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study.

Factors Influencing Allopurinol Initiation in Primary Care (2017)
Journal Article

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice (2015)
Journal Article

Osteoarthritis is a leading cause of chronic pain and disability and one of the most common conditions diagnosed and managed in primary care. Despite the evidence that patients would value discussions about the course of osteoarthritis to help them m... Read More about Discussing prognosis with patients with osteoarthritis: a cross-sectional survey in general practice.