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All Outputs (59)

Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia (2023)
Journal Article
Ostini, A., & Mourtada-Maarabouni, M. (2023). Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia. Non-Coding RNA, 9(4), Article 47. https://doi.org/10.3390/ncrna9040047

Myocardial Infarction Associated Transcript (MIAT) is a nuclear long non-coding RNA (LncRNA) with four different splicing variants. MIAT dysregulation is associated with carcinogenesis, mainly acting as an oncogene regulating cellular growth, invasio... Read More about Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia.

New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate (2023)
Journal Article
Kavousi, N., Tonge, D. P., & Mourtada-Maarabouni, M. (2023). New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate. International Journal of Biological Macromolecules, 233, Article 123467. https://doi.org/10.1016/j.ijbiomac.2023.123467

The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour suppressor. Emerging evidence suggests t... Read More about New insights into the functional role of protein phosphatase 4 regulatory subunit PP4R3A/SMEK1 in the regulation of leukemic cell fate.

The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions (2020)
Journal Article
Frank, F., Kavousi, N., Bountali, A., B. Dammer, E., Mourtada-Maarabouni, M., & A. Ortlund, E. (2020). The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions. Cell Reports, https://doi.org/10.1016/j.celrep.2020.107933

There is increasing evidence that the architecture of long non-coding RNAs (lncRNAs) just like that of proteins-is hierarchically organized into independently folding sub-modules with distinct functions. Studies characterizing the cellular activities... Read More about The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions.

SAT-LB138 The LncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules With Independent Functions (2020)
Journal Article
Frank, F., Kavousi, N., Bountali, A., Dammer, E., Mourtada-Maarabouni, M., & Ortlund, E. (2020). SAT-LB138 The LncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules With Independent Functions. Journal of the Endocrine Society, https://doi.org/10.1210/jendso/bvaa046.2327

The growth arrest-specific 5 (gas5) gene encodes a long non-coding RNA (lncRNA) that is required for normal growth arrest, slows down the cell cycle, controls apoptosis, and is required for the inhibition of cell growth by mTOR inhibitors such as rap... Read More about SAT-LB138 The LncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules With Independent Functions.

RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate (2019)
Journal Article
Bountal, A., Tonge, D. P., & Mourtada-Maarabouni, M. (2019). RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate. International Journal of Biological Macromolecules, 878-891. https://doi.org/10.1016/j.ijbiomac.2019.03.005

Myocardial Infarction Associated Transcript (MIAT) is a subnuclear lncRNA that interferes with alternative splicing and is associated with increased risk of various heart conditions and nervous system tumours. The current study aims to elucidate the... Read More about RNA sequencing reveals a key role for the long non-coding RNA MIAT in regulating neuroblastoma and glioblastoma cell fate.

Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells (2018)
Conference Proceeding
Bountali, K., Maarabouni, M., & Tonge, D. (2018). Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells. . https://doi.org/10.1136/esmoopen-2018-EACR25.861

Abstract Introduction Of the total human DNA only 1.2% o codes for proteins, with the rest only being transcribed into regulatory RNA, known as non-coding RNA. Long non-coding RNAs (lncRNAs) are non-coding RNAs that have no or limited protein-coding... Read More about Identification of differentially expressed lncrnas in metformin resistant SH-SY5Y neuroblastoma cells.

Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines (2018)
Journal Article
Almnaseer, Z. A., & Mourtada-Maarabouni, M. (2018). Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines. Bioscience Reports, 38(4), https://doi.org/10.1042/BSR20180704

The long noncoding RNA myocardial infarction associated transcript (MIAT) is involved in a number of diseases, including myocardial infarction and diabetic retinopathy. Emerging evidence suggests that MIAT expression levels are increased in different... Read More about Long noncoding RNA MIAT regulates apoptosis and the apoptotic response to chemotherapeutic agents in breast cancer cell lines.

Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia (2016)
Presentation / Conference
Mourtada Maarabouni, M., Hanson, R., Sivanandan, C., & Ladna, A. (2016, November). Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia. Presented at NCRI Cancer Conference, Liverpool

Abstract Background The serine/ threonine protein phosphatase 4 (PP4) has been identified to play a role in apoptosis and tumorigenesis. The PP4 holoenzyme consists of PP4 catalytic subunit (PP4c) which interacts with four different regulatory... Read More about Role of Protein Phosphatase 4 Regulatory Subunits in Myeloid Leukaemia.

The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells (2016)
Journal Article
Mohammed, H. N., Pickard, M. R., & Mourtada-Maarabouni, M. (2016). The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. Cellular Signalling, 1389 - 1400. https://doi.org/10.1016/j.cellsig.2016.06.011

Background: The control of breast cell survival is of critical importance for preventing breast cancer initiation and progression. The activity of many proteins which regulate cell survival is controlled by reversible phosphorylation, so that the re... Read More about The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.

The vacuolar ATPase subunit E controls apoptosis and is down-regulated in breast cancer (2015)
Presentation / Conference
Mohammed, S., & Mourtada-Maarabouni, M. (2015, November). The vacuolar ATPase subunit E controls apoptosis and is down-regulated in breast cancer. Poster presented at 11th NCRI Cancer Conference, Liverpool

Background Vacuolar H+-ATPase (v-ATPase) is a large multisubunit proton pump that mediates the acidification of many intracellular compartments. Previous studies have strongly implicated v-ATPase in carcinogenesis and tumour progression and indicat... Read More about The vacuolar ATPase subunit E controls apoptosis and is down-regulated in breast cancer.

Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate (2014)
Journal Article
Hudson, W. H., Pickard, M. R., de Vera, I. M. S., Kuiper, E. G., Mourtada-Maarabouni, M., Conn, G. L., …Ortlund, E. A. (2014). Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate. Nature Communications, 5(1), Article 5395. https://doi.org/10.1038/ncomms6395

The majority of the eukaryotic genome is transcribed, generating a significant number of long intergenic noncoding RNAs (lincRNAs). Although lincRNAs represent the most poorly understood product of transcription, recent work has shown lincRNAs fulfil... Read More about Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.