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All Outputs (68)

Early Intervention in Psychosis and Management of First Episode Psychosis in Low- and Lower-Middle-Income Countries: A Systematic Review (2024)
Journal Article

Background and Hypothesis People with first-episode psychosis (FEP) in low- and lower-middle-income countries (LMIC) experience delays in receiving treatment, resulting in poorer outcomes and higher mortality. There is robust evidence for effective a... Read More about Early Intervention in Psychosis and Management of First Episode Psychosis in Low- and Lower-Middle-Income Countries: A Systematic Review.

The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol (2023)
Journal Article

Pain is a major challenge for patients with inflammatory arthritis (IA). Depression and anxiety are common comorbidities in IA, associating with worse outcomes. How they relate to pain is uncertain, with existing systematic reviews (a) mainly conside... Read More about The relationship between pain and depression and anxiety in patients with inflammatory arthritis: a systematic review protocol.

Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial (2023)
Journal Article

Objectives In low/middle-income countries (LMICs), more than half of patients with first-episode psychosis initially seek treatment from traditional and religious healers as their first care. This contributes to an excessively long duration of untrea... Read More about Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial.

Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial (2023)
Journal Article

Objectives: In low/middle-income countries (LMICs), more than half of patients with first-episode psychosis initially seek treatment from traditional and religious healers as their first care. This contributes to an excessively long duration of untre... Read More about Traditional healers working with primary care and mental health for early intervention in psychosis in young persons: protocol for the feasibility cluster randomised controlled trial.

Role of Primary Care Physicians in management of Schizophrenia in Low and Middle Income Countries (LMIC): A systematic review (2023)
Journal Article

Many people with Schizophrenia lack the resources and access to mental health services especially in low and middle income countries. Integration of mental health into primary care services can be a cost effective way of reducing the disability assoc... Read More about Role of Primary Care Physicians in management of Schizophrenia in Low and Middle Income Countries (LMIC): A systematic review.

Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan. (2023)
Journal Article

INTRODUCTION: Globally, 80% of the burdenof major depressive disorder (MDD) pertains to low- and middle-income countries. Research into genetic and environmental risk factors has the potential to uncover disease mechanisms that may contribute to bett... Read More about Study protocol of DIVERGE, the first genetic epidemiological study of major depressive disorder in Pakistan..

Cluster A personality disorders and potential for early intervention in psychosis: Challenges and opportunities (2022)
Book Chapter

The ‘Cluster A’ personality disorders consist of paranoid, schizoid and schizotypal personality disorders. The common features of personality disorders in this cluster are social awkwardness, social withdrawal, odd or eccentric behaviour and distorte... Read More about Cluster A personality disorders and potential for early intervention in psychosis: Challenges and opportunities.

Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study (2022)
Journal Article

OBJECTIVE: To explore the perceptions and experiences of schizophrenia from patients, their care givers, health care providers, spiritual and traditional healers to develop a community-based intervention for improving treatment adherence for people w... Read More about Patients’ and healthcare professionals’ perspectives on a community-based intervention for schizophrenia in Pakistan: A focus group study.

Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia (2022)
Journal Article

ABSTRACTIntroductionTreatment Resistant Schizophrenia (TRS) is associated with significant impairment of functioning and high treatment costs. Identification of patients at high risk of TRS at their initial diagnosis may significantly improve clinica... Read More about Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia.

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (2021)
Journal Article

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and... Read More about An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. (2021)
Journal Article

We aimed to review the literature on interventions for treating Common Mental Disorders (CMD) in people with Tuberculosis (TB). We followed PRISMA guidelines and the protocol was registered at PROSPERO. The electronic databases (PsycInfo, CINAHL, Med... Read More about Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review..

Self-reported health and smoking status, and body mass index: a case-control comparison based on GEN SCRIP (GENetics of SChizophRenia In Pakistan) data (2021)
Journal Article

Introduction Individuals with schizophrenia are at a high risk of physical health comorbidities and premature mortality. Cardiovascular and metabolic causes are an important contributor. There are gaps in monitoring, documenting and managing these ph... Read More about Self-reported health and smoking status, and body mass index: a case-control comparison based on GEN SCRIP (GENetics of SChizophRenia In Pakistan) data.

Switching antipsychotics to support the physical health of people with severe mental illness: A qualitative study of healthcare professionals' perspectives (2021)
Journal Article

OBJECTIVES: The side effects of antipsychotic medications (APs) can increase the risk of developing physical health conditions. Some APs pose a higher risk than others. Evidence suggests switching to lower risk APs can support physical health outcome... Read More about Switching antipsychotics to support the physical health of people with severe mental illness: A qualitative study of healthcare professionals' perspectives.