All Outputs (18)

Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells (2023)
Journal Article

Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of proteotoxic... Read More about Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells.

Acidic PH inhibits the stiffness response in human bone marrow mesenchymal stem cells (BM-MSCS) (2023)
Journal Article

Acidic pH inhibits the stiffness response of human bone-marrow mesenchymal stem cells (BM-MSCs) (2023)
Presentation / Conference

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence (2022)
Journal Article

ABSTRACT Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche exp... Read More about Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence.

Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation (2020)
Journal Article

Growth differentiation factor (GDF) family members have been implicated in the development and maintenance of healthy nucleus pulposus (NP) tissue, making them promising therapeutic candidates for treatment of intervertebral disc (IVD) degeneration a... Read More about Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation.

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion (2019)
Journal Article

Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading (2019)
Journal Article

The consequences of ageing, progeroid syndromes and cellular senescence on mechanotransduction and the nucleus (2019)
Journal Article

An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness (2018)
Journal Article

Degenerate intervertebral disc‐like pH induces a catabolic mechanoresponse in human nucleus pulposus cells (2018)
Journal Article

Molecular Pathways of Mechanotransduction: From Extracellular Matrix to Nucleus (2016)
Book Chapter

Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target (2016)
Journal Article

Interior decoration: Adapting multiwell plates for high throughput mechanobiology (2015)
Journal Article

In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering (2014)
Journal Article

A microstereolithography resin based on thiol-ene chemistry: towards biocompatible 3D extracellular constructs for tissue engineering (2013)
Journal Article

Stem Cell Regeneration of Degenerated Intervertebral Discs: Current Status (Update) (2013)
Journal Article

Integrin – Dependent Mechanotransduction in Mechanically Stimulated Human Annulus Fibrosus Cells: Evidence for an Alternative Mechanotransduction Pathway Operating with Degeneration (2013)
Journal Article

Fabrication of 3-Dimensional Cellular Constructs via Microstereolithography Using a Simple, Three-Component, Poly(Ethylene Glycol) Acrylate-Based System (2012)
Journal Article