Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform

Denning, Chris; Borgdorff, Viola; Crutchley, James; Firth, Karl S.A.; George, Vinoj; Kalra, Spandan; Kondrashov, Alexander; Duc Hoang, Minh; Mosqueira, Diogo; Patel, Asha; Prodanov, Ljupcho; Rajamohan, Divya; Skarnes, William C.; Smith, James G.W.; Young, Lorraine E.

doi:10.1016/j.bbamcr.2015.10.014

All Outputs (4)

Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials (2019)
Journal Article

Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all th... Read More about Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials.

Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (2017)
Journal Article

Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now a well-established modality for modeling genetic disorders of the heart. This is especially so for long QT syndrome (LQTS), which is caused by perturbation of ion... Read More about Drug-Mediated Shortening of Action Potentials in LQTS2 Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes..

Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes (2016)
Journal Article

Automated planar patch clamp systems are widely used in drug evaluation studies because of their ability to provide accurate, reliable, and reproducible data in a high-throughput manner. Typically, CHO and HEK tumorigenic cell lines overexpressing si... Read More about Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform (2015)
Journal Article

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise biomedicine. Global burden of heart failure will soon reach USD $90bn, while unexpected cardiotoxicity underlies 28% of drug withdrawals. Advances in hPSC isolation, Cas... Read More about Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.