All Outputs (7)

Developing in vitro models of traumatic injury for neural tissue engineering applications (2023)
Thesis
Wiseman, J. P. (2023). Developing in vitro models of traumatic injury for neural tissue engineering applications. (Thesis). Keele University

Penetrating traumatic brain injury (pTBI) and spinal cord injury (SCI) cause significant neurological damage and debilitation. The management of these central nervous system (CNS) injuries is largely supportive, with no clinically available regenerat... Read More about Developing in vitro models of traumatic injury for neural tissue engineering applications.

Developing tools for inter-site transport of brain tissue models in tissue engineering research (2022)
Thesis
Kabiri, B. (2022). Developing tools for inter-site transport of brain tissue models in tissue engineering research. (Thesis). Keele University

Penetrating traumatic brain injury (pTBI) remains one of the leading causes of death in the younger population in the UK, as no clinical regenerative therapies are available. Experimental therapies currently being screened for efficacy are wide rangi... Read More about Developing tools for inter-site transport of brain tissue models in tissue engineering research.

Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials (2022)
Thesis
Chowdhury, F. (2022). Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials. (Thesis). Keele University

Oligodendrocyte lineage and neuronal cells are essential neural populations required for axonal remyelination after spinal cord injury (SCI). Injection of an exogenous cell population into the site of neural injury has posed translational barriers, s... Read More about Cell models to evaluate oligodendrocyte lineage cell growth on biomaterials.

Developing neural transplant cell sprays for neurological injuries (2020)
Thesis
Woods, W. A. (2020). Developing neural transplant cell sprays for neurological injuries. (Thesis). Keele University

Regeneration of the central nervous system following penetrating traumatic brain injury (pTBI) represents a significant clinical challenge. Neural cell therapies have the potential to promote regeneration in central neural injury. However, such thera... Read More about Developing neural transplant cell sprays for neurological injuries.

New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies (2020)
Thesis
Basit, R. H. (2020). New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418094

Penetrating traumatic brain injury (pTBI) causes significant neural damage and debilitation. The management of pTBI is largely supportive currently, with no clinically established regenerative therapies. Researchers have previously evaluated the rege... Read More about New in vitro model of traumatic brain injury to assess biomaterial based regenerative strategies.

Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials (2018)
Thesis
Finch, L. (2018). Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418125

Achieving neural regeneration after spinal cord injury (SCI) represents a significant challenge. Neural stem cell (NSC) therapy offers replacement of damaged cells and delivery of pro-regenerative factors, but >95% of cells die when transplanted to s... Read More about Delivering nanoengineered neural stem cells within neurosurgical grade biomaterials.

Magnetic assistive and hydrogel technology for enhanced survival and function of neurons (2018)
Thesis
Al-Shakli, A. F. (2018). Magnetic assistive and hydrogel technology for enhanced survival and function of neurons. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411469

Neurons are the targets of injury and disease in many neurological conditions, and achieving neuronal survival/repair is a key goal for regenerative medicine. In this context, genetic engineering of neurons offers a platform for (i) basic research to... Read More about Magnetic assistive and hydrogel technology for enhanced survival and function of neurons.