All Outputs (4)

Chemical synthesis of fluorinated carbocyclic nucleoside analogues (2023)
Thesis

Since the discovery of their pharmaceutical potential, nucleoside analogues have become one of the most important classes of chemotherapeutic agents in the treatment of many cancers and viral infections. In many chronic illnesses, such as HBV or HIV... Read More about Chemical synthesis of fluorinated carbocyclic nucleoside analogues.

Chemical synthesis and biological evaluation of 4'-thionucleosides (2022)
Thesis

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers and viruses. Several such compounds, including Sofosbuvir and Gemcitabine are the go-to option in first line treatments. Ho... Read More about Chemical synthesis and biological evaluation of 4'-thionucleosides.

Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates (2020)
Thesis

Alginate is an anionic polysaccharide comprised of β˗1,4˗linked D˗mannuronic acid (M) and L˗guluronic acid (G). The polymer is naturally harvested from seaweed and is widely exploited in various biotechnological and biomedical applications, due to th... Read More about Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates.

Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa (2020)
Thesis

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterium, responsible for causing life threatening infections amongst fibrosis (CF) patients. Mucoid phenotypes of P. aeruginosa are characterised by overproduction of alginate, an extra-cel... Read More about Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa.