Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs)

Sykes, Jessica Grace

All Outputs (5)

Characterisation of Bone Marrow Aspirate Concentrate with Thrombin Used for Repairing Osteochondral Lesions of the Talus (2025)
Journal Article
Lan, T., Wright, K. T., Makwana, N., Bing, A., Hulme, C. H., & McCarthy, H. S. (2025). Characterisation of Bone Marrow Aspirate Concentrate with Thrombin Used for Repairing Osteochondral Lesions of the Talus. The Journal of Cartilage & Joint Preservation, Article 100237. https://doi.org/10.1016/j.jcjp.2025.100237

A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation (2024)
Journal Article
Orfanos, G., McCarthy, H. S., Williams, M., Dugard, N., Gallacher, P. D., Glover, A. W., Roberts, S., Wright, K. T., & Kuiper, J. H. (2024). A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation. Cartilage, https://doi.org/10.1177/19476035241279943

Objective
Traditional autologous chondrocyte implantation (ACI) involves arthroscopically harvesting a cartilage biopsy (stage 1), followed by arthrotomy 3-4 weeks later to apply a periosteal patch and implant culture-expanded chondrocytes underneat... Read More about A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation.

Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes (2024)
Thesis
Tierney, L. J. Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775433

Autologous chondrocyte implantation (ACI) has repeatedly been shown to be an effective treatment for cartilage defects within the knee and can delay or prevent the need for a total knee replacement. However, the level of clinical benefit experienced... Read More about Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes.

Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications (2021)
Thesis
Wang, J. Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications. (Thesis). Keele University. https://keele-repository.worktribe.com/output/420665

As a vital part of the knee joint, the meniscus acts to prevent the degeneration of articular cartilage and the onset of knee osteoarthritis (OA). Repairing meniscus injuries in the avascular region is still a challenge in orthopaedics. The current p... Read More about Cell-based meniscus characterization and regeneration: basic science, tissue engineering and clinical applications.

Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs) (2019)
Thesis
Sykes, J. G. Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs). (Thesis). Keele University. https://keele-repository.worktribe.com/output/414327

Autologous chondrocyte implantation (ACI) is the only UK approved cell therapy or knee cartilage defects which might otherwise progress to osteoarthritis. For ACI, chondrocytes isolated from a healthy cartilage biopsy are expanded in number prior to... Read More about Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs).