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All Outputs (7)

Determining the role of epigenetics in telomerase regulation (2022)
Thesis
Dogan, F. (2022). Determining the role of epigenetics in telomerase regulation. (Thesis). Keele University

Telomeres are guanine-rich 5'-TTAGGG-3' repeats found at the ends of human chromosomes that protect chromosomes from degradation and also provide stabilization. Telomerase macromolecule is the primary enzyme responsible for telomere elongation. Telom... Read More about Determining the role of epigenetics in telomerase regulation.

A novel scaffold for cell-based lung tissue engineering (2022)
Thesis
Kyoseva, A. Y. (2022). A novel scaffold for cell-based lung tissue engineering. (Thesis). Keele University

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and numbers are rising. Tissue engineering approaches have the potential to improve lung function and treat diseases such as COPD. Our aim is to investigate a... Read More about A novel scaffold for cell-based lung tissue engineering.

Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo (2020)
Thesis
Turner, D. C. (2020). Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo. (Thesis). Keele University

Skeletal muscle (SkM) is an extremely abundant and mechano-sensitive tissue, demonstrating increases in mass and function following mechanical loading/resistance exercise (RE). Over the past 3 decades, there has been considerable progress in the deve... Read More about Mechanical loading of bioengineered skeletal muscle in-vitro to mimic the transcriptional and epigenetic regulation of skeletal muscle in-vivo.

Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia (2019)
Thesis
Bratt, J. A. (2019). Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415216

Bronchopulmonary dysplasia (BPD) is a neonatal disease affecting the lungs of premature infants. Prematurely born infants have under-developed lungs and require invasive ventilation technologies to provide sufficient oxygen for survival. Artificial v... Read More about Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia.

Exploring the effects of gestational diabetes on placental membrane derived stem cells (2019)
Thesis
Chen, L. (2019). Exploring the effects of gestational diabetes on placental membrane derived stem cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414443

The progression of regenerative medicine and advanced cell banking technology provide the hope of using perinatal tissue-derived autologous MSCs for personalised medicine. Mesenchymal stem cells (MSCs) derived from placenta, with the advantages of be... Read More about Exploring the effects of gestational diabetes on placental membrane derived stem cells.

Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration (2019)
Thesis
Younus, Z. M. (2019). Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413770

Osteochondral defects are serious clinical problems relating to damaged articular cartilage within joints, usually resulting from acute traumatic injury or an underlying bone disorder. A variety of therapeutic options have been investigated, with sev... Read More about Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration.

Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. (2018). Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.