All Outputs (6)

The potential of small extracellular vesicles for pancreatic cancer therapy (2025)
Journal Article
Crow, R., Kehoe, O., & Hoskins, C. (2025). The potential of small extracellular vesicles for pancreatic cancer therapy. RSC Pharmaceutics. https://doi.org/10.1039/d5pm00115c

Extracellular vesicles come in various shapes and sizes and are released by most cell types. They have myriad roles in intercellular signalling in both physiological and pathological environments, carrying a range of lipids, proteins and nucleic acid... Read More about The potential of small extracellular vesicles for pancreatic cancer therapy.

Scaling up mesenchymal stromal cell extracellular vesicle production for therapeutic application in rheumatoid arthritis (2025)
Thesis
Davies, R. L. (2025). Scaling up mesenchymal stromal cell extracellular vesicle production for therapeutic application in rheumatoid arthritis [Doctoral thesis, Keele University]. https://keele-repository.worktribe.com/output/1280129

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease. Given the complexity of RA and current treatment limitations, mesenchymal stromal cell extracellular vesicles (MSC EVs) have been proposed as an alternative. These small membrane-... Read More about Scaling up mesenchymal stromal cell extracellular vesicle production for therapeutic application in rheumatoid arthritis.

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
Journal Article
Kehoe, O., Welsh, J. A., Goberdhan, D. C., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Whitley, J., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Kiang Lim, S., Mahoney, M. G., Mohanty, S., Möller, A., …Witwer, K. W. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have
generated b... Read More about Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

ST2-Conditioned Medium Fosters Dorsal Horn Cell Excitability and Synaptic Transmission in Cultured Mouse Spinal Cord. (2023)
Journal Article
Juárez, E. H., Wood, C. R., Davies, R., Kehoe, O., Johnson, W. E., Merighi, A., & Ferrini, F. (2023). ST2-Conditioned Medium Fosters Dorsal Horn Cell Excitability and Synaptic Transmission in Cultured Mouse Spinal Cord. Stem Cell Reviews and Reports, 19, 2918-2928. https://doi.org/10.1007/s12015-023-10618-x

Conditioned medium obtained from bone marrow-derived stem cells has been proposed as a novel cell-free therapy in spinal cord injury and neuropathic pain, yet the direct effect on spinal neuron function has never been investigated. Here, we adopted s... Read More about ST2-Conditioned Medium Fosters Dorsal Horn Cell Excitability and Synaptic Transmission in Cultured Mouse Spinal Cord..

Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells (2021)
Thesis
Hyland, M. Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells. (Thesis). Keele University. https://keele-repository.worktribe.com/output/421730

Rheumatoid Arthritis (RA) is a chronic autoimmune disease which is characterised by a loss of immune tolerance, and an infiltration of immune cells into joints causing inflammation. Current pharmaceutical treatments for RA have adverse side effects a... Read More about Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells.

Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies (2020)
Thesis
Morgan, R. L. (2020). Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies [Doctoral thesis, Keele University]. https://keele-repository.worktribe.com/output/417176

Cells secrete small membrane-bound extracellular vesicles (sEVs) called exosomes. These vesicles contain a mixture of protein, lipids, nucleic acids and saccharides (known collectively as cargo) that mediate therapeutic effects similar to their produ... Read More about Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies.