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All Outputs (2)

Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection (2019)
Thesis
Channell, J. A. (2019). Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413133

Cluster of differentiation 4 (CD4) is a receptor protein found on the surface of cells of the immune system and is the primary receptor of the human immuno-deficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120). The extracellular portion of CD4... Read More about Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection.

Towards an understanding of amyloidogenesis: a structural and biophysical analysis of transthyretin (2018)
Thesis
Yee, A. W. (2018). Towards an understanding of amyloidogenesis: a structural and biophysical analysis of transthyretin. (Thesis). Keele University

Human transthyretin (TTR) is heavily implicated in a range of fatal amyloid diseases. The propensity to form amyloid varies between wild-type TTR and various mutants. In all cases this occurs by tetramer dissociation to a monomeric form, which in tur... Read More about Towards an understanding of amyloidogenesis: a structural and biophysical analysis of transthyretin.