All Outputs (1604)

An investigation of magnetic nanoparticle mediated methods for neuro-regeneration (2024)
Thesis

Conditions such as Parkinsons disease, where specific cell types are affected such as the dopaminergic neurons in the substantia nigra pars compacta, cell transplantation and growth factor therapy could restore function and slow disease progression b... Read More about An investigation of magnetic nanoparticle mediated methods for neuro-regeneration.

Physical properties of eclipsing binaries containing intermediate-mass pulsators or low-mass stars (2024)
Thesis

Precise stellar parameter measurements are crucial for improving our theoretical understanding of stellar structure. They help quantify model errors and uncertainties and provide vital constraints for interpreting observed phenomena, such as radius i... Read More about Physical properties of eclipsing binaries containing intermediate-mass pulsators or low-mass stars.

Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles (2024)
Thesis

The need for clean energy is not being met and is increasing each day. One immensely underused technology – proton exchange membrane fuel cells, can drastically help to deliver green energy and prevent the worsening of climate change. However, in ord... Read More about Comprehensive utilisation of hydrogen gas for the efficient use of proton exchange membrane fuel cell powered vehicles.

Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes (2024)
Thesis

Coronary artery disease ( CAD) remains the leading cause of death worldwide. Medical therapy and lifestyle modifications are the first line of therapy to minimise symptoms and retard disease progression. An Invasive therapy in the form of percutaneou... Read More about Complex, high-risk but Indicated Percutaneous Coronary Interventions (CHiP) types, trends, and clinical outcomes.

Exoplanet radius measurements for short-period exoplanets observed by the CHEOPS mission (2024)
Thesis

Context. Scheduling observing time for the CHEOPS mission leaves short gaps in which the telescope goes unused. If data collected during these gaps provided quality results, they could be utilised to make observing time more efficient. Aims. The ai... Read More about Exoplanet radius measurements for short-period exoplanets observed by the CHEOPS mission.

Political attitudes and social change: The role of intergroup contact and social identity complexity (2024)
Thesis

This thesis explores the impact of intergroup contact on political attitudes via social identity complexity (SIC) across WEIRD and non-WEIRD societies, including post-conflict contexts. This research aims to test whether and how dimensions of intergr... Read More about Political attitudes and social change: The role of intergroup contact and social identity complexity.

The performance and politics of memory-work in contemporary documentary film: transforming violent pasts (2024)
Thesis

This thesis investigates the dynamics of ‘memory-work’ in contemporary documentary films that deal with painful pasts involving violence. The analysis will focus on four recently produced documentary films. Memory-work in this thesis is understood as... Read More about The performance and politics of memory-work in contemporary documentary film: transforming violent pasts.

Why groups don’t forgive: refining the contributions of ingroup identity, ingroup attachment, justice concerns, and conflict type to intergroup forgiveness (2024)
Thesis

Researchers have begun to investigate the role of forgiveness in disrupting intergroup conflict and promoting peace. This thesis has refined our understanding of the ingroup identity and forgiveness relationship by determining which ingroup identity... Read More about Why groups don’t forgive: refining the contributions of ingroup identity, ingroup attachment, justice concerns, and conflict type to intergroup forgiveness.

Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma (2024)
Thesis

Background: In 2020, the NHS developed its carbon net zero goals and highlighted metered dose inhalers (MDIs) as a focal point for change. MDIs are commonly prescribed for asthma in primary care and contain potent greenhouse gases, accounting for 3%... Read More about Greener Asthma Prescribing: A qualitative study exploring primary healthcare professional perspectives on reducing prescribing of metered dose inhalers for asthma.

Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes (2024)
Thesis

Autologous chondrocyte implantation (ACI) has repeatedly been shown to be an effective treatment for cartilage defects within the knee and can delay or prevent the need for a total knee replacement. However, the level of clinical benefit experienced... Read More about Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes.

Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis (2024)
Thesis

Background: Axial spondyloarthritis (axSpA) causes inflammation of the pelvis and spine, resulting in chronic pain, impaired range of movement, fatigue and physical disability. Diagnosis remains challenging and is frequently delayed, resulting in poo... Read More about Understanding the barriers, facilitators and extent of diagnostic delay in axial spondyloarthritis.

New approaches to diagnosing exact recurrent flows embedded in two-dimensional turbulence (2024)
Thesis

Turbulent flow is often viewed as a trajectory wandering through a high dimensional phase-space, momentarily visiting the neighbourhood of unstable invariant solutions, e.g. unstable periodic orbits, travelling waves and equilibria. Periodic orbit th... Read More about New approaches to diagnosing exact recurrent flows embedded in two-dimensional turbulence.

Lay, professional, and police rape stereotype acceptance in England and Wales: A holistic, mixed-methods overview of the Criminal Justice System (2023)
Thesis

This thesis examined rape stereotype acceptance and use in England and Wales, viewed through the lens of Social Representations Theory (SRT). Given the high attrition rate and low prosecution rate for rape, the project was a holistic look at stereoty... Read More about Lay, professional, and police rape stereotype acceptance in England and Wales: A holistic, mixed-methods overview of the Criminal Justice System.

Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research (2023)
Thesis

Intravital microscopy in mice is widely used to study in vivo thrombus formation, however, the relevance of these studies to human physiology is unclear. In this thesis, a 3D tissue-engineered human arterial construct (TEAC) was developed that replic... Read More about Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research.

FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice? (2023)
Thesis

Cancer incidence rates are increasing world-wide including in the UK. An increase in cancer cases puts further pressure on pathology departments that are often already struggling to meet targets to diagnose cancers in a timely manner. Delays in diagn... Read More about FTIR Spectroscopy for cancer diagnosis. How can glass substrates be used to bring it closer to clinical practice?.

Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy (2023)
Thesis

LMNA-related congenital muscular dystrophy (L-CMD) is a rare disorder predominantly causing muscle weakness and wasting, over time, leading to development of dysphagia and life-threating respiratory insufficiency, and sometimes cardiac arrhythmias. T... Read More about Characterising the molecular consequences of LMNA mutations in congenital muscular dystrophy.

Hydrodynamic simulations of convection and nucleosynthesis in the late phases of massive stars to constrain and guide stellar evolution theory (2023)
Thesis

The present knowledge of stellar evolution is still limited today by large uncertainties that derive from the complex multi-dimensional processes occurring in stars. Among them, the turbulent motions of the stellar fluid control the size and evolutio... Read More about Hydrodynamic simulations of convection and nucleosynthesis in the late phases of massive stars to constrain and guide stellar evolution theory.

Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques (2023)
Thesis

Non-degradable and biodegradable implants inevitably generate debris or degradation products in the body, and these induce acute and chronic inflammation. Polyglycolic acid (PGA) is a simple linear aliphatic polyester with a wide set of medical appli... Read More about Unravelling the immunomodulatory effect of Poly (glycolic acid) particles using new techniques.

The role of physiotherapy in polymyalgia rheumatica in the United Kingdom: a mixed method study (2023)
Thesis

Background: Polymyalgia Rheumatica (PMR) is the commonest rheumatic condition affecting older people, typically treated with glucocorticoids. However, the treatment side-effects including fatigue, anxiety and other alterations in mood, are frequent a... Read More about The role of physiotherapy in polymyalgia rheumatica in the United Kingdom: a mixed method study.

Modelling and forecasting oil market volatility: A regime switching GARCH MIDAS approach (2023)
Thesis

In this thesis, we consider a regime switching GARCH MIDAS model with Student-t innovations. By allowing the error term to be non-Gaussian, we want to see how effective it is in describing the volatility displayed in financial time series. For the lo... Read More about Modelling and forecasting oil market volatility: A regime switching GARCH MIDAS approach.