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Saeed Farooq's Outputs (95)

Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia (2022)
Other
Farooq, S., Hattle, M., Dazzan, P., Kingstone, T., Ajnakina, O., Shiers, D., Antonietta Nettis, M., Lawrence, A., Riley, R. D., & van der Windt, D. A. (2022). Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia

Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (2022)
Journal Article
de Leon, J., Schoretsanitis, G., Smith, R. L., Molden, E., Solismaa, A., Seppälä, N., Kopeček, M., Švancer, P., Olmos, I., Ricciardi, C., Iglesias-Garcia, C., Iglesias-Alonso, A., Spina, E., Ruan, C.-J., Wang, C.-Y., Wang, G., Tang, Y.-L., Lin, S.-K., Lane, H.-Y., Kim, Y. S., …Müller, D. J. (2022). Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry, 55(02), e1-e1. https://doi.org/10.1055/a-1737-1527

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels (2021)
Journal Article
de Leon, J., Schoretsanitis, G., Smith, R. L., Molden, E., Solismaa, A., Seppälä, N., Kopeček, M., Švancer, P., Olmos, I., Ricciardi, C., Iglesias-Garcia, C., Iglesias-Alonso, A., Spina, E., Ruan, C.-J., Wang, C.-Y., Wang, G., Tang, Y.-L., Lin, S.-K., Lane, H.-Y., Kim, Y. S., …Marder, S. R. (2021). An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry, 55(02), 73-86. https://doi.org/10.1055/a-1625-6388

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and... Read More about An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

Suicide, self-harm and suicidal ideation during COVID-19: A systematic review (2021)
Journal Article
Farooq, S., Tunmore, J., Ali, W., & Ayub, M. (2021). Suicide, self-harm and suicidal ideation during COVID-19: A systematic review. Psychiatry Research, 306, Article ARTN 114228. https://doi.org/10.1016/j.psychres.2021.114228

We aimed to do a systematic review and meta-analysis of studies describing suicidal ideation, suicide attempts and suicide and associated risk factors during COVID-19 pandemic. We searched following electronic databases using relevant search terms: M... Read More about Suicide, self-harm and suicidal ideation during COVID-19: A systematic review.

The haematological side effects of clozapine: literature review and meta-analysis (2021)
Presentation / Conference Contribution
Munshi, T., Naeem, F., Ayub, M., Farooq, S., Khachatryan, D., Asmer, S., Wang, P., Premji, S., Van Winssen, C., Lau, F., & Fairbairn, J. The haematological side effects of clozapine: literature review and meta-analysis. Presented at RCPsych Virtual International Congress

Aims
This review and meta-analysis aim to estimate the cumulative incidence of clozapine induced agranulocytosis and leukopenia the impact of the associated factors such as dose of clozapine, duration of follow-up, gender and race on the cumulative... Read More about The haematological side effects of clozapine: literature review and meta-analysis.

Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. (2021)
Journal Article
Farooq, S. (2021). Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. Chronic Respiratory Disease, -. https://doi.org/10.1177/14799731211003937

We aimed to review the literature on interventions for treating Common Mental Disorders (CMD) in people with Tuberculosis (TB). We followed PRISMA guidelines and the protocol was registered at PROSPERO. The electronic databases (PsycInfo, CINAHL, Med... Read More about Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review..

Self-reported health and smoking status, and body mass index: a case-control comparison based on GEN SCRIP (GENetics of SChizophRenia In Pakistan) data (2021)
Journal Article
Farooq. (2021). Self-reported health and smoking status, and body mass index: a case-control comparison based on GEN SCRIP (GENetics of SChizophRenia In Pakistan) data. BMJ Open, 1-9. https://doi.org/10.1136/bmjopen-2020-042331

Introduction Individuals with schizophrenia are at a high risk of physical health comorbidities and premature mortality. Cardiovascular and metabolic causes are an important contributor. There are gaps in monitoring, documenting and managing these ph... Read More about Self-reported health and smoking status, and body mass index: a case-control comparison based on GEN SCRIP (GENetics of SChizophRenia In Pakistan) data.

Switching antipsychotics to support the physical health of people with severe mental illness: A qualitative study of healthcare professionals' perspectives (2021)
Journal Article
Nash, A., Kingstone, T., Farooq, S., Tunmore, J., & Chew-Graham, C. A. (2021). Switching antipsychotics to support the physical health of people with severe mental illness: A qualitative study of healthcare professionals' perspectives. BMJ Open, e042497 - ?. https://doi.org/10.1136/bmjopen-2020-042497

OBJECTIVES: The side effects of antipsychotic medications (APs) can increase the risk of developing physical health conditions. Some APs pose a higher risk than others. Evidence suggests switching to lower risk APs can support physical health outcome... Read More about Switching antipsychotics to support the physical health of people with severe mental illness: A qualitative study of healthcare professionals' perspectives.

Scarlett Letter: A study based on experience of stigma by COVID-19 patients in quarantine (2020)
Journal Article
Farooq. (2020). Scarlett Letter: A study based on experience of stigma by COVID-19 patients in quarantine. https://doi.org/10.12669/pjms.36.7.3606

Background and Objectives: Stigma around COVID-19 is a major barrier in global efforts to control the COVID 19 pandemic. Limited data is available regarding stigma faced by COVID-19 patients in low- and middle-income countries (LMIC).... Read More about Scarlett Letter: A study based on experience of stigma by COVID-19 patients in quarantine.

Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes (2020)
Presentation / Conference Contribution
Mohamed, M., Rashid, M., Farooq, S., Siddiqui, N., Parwani, P., Shiers, D., Thamman, R., Gulati, M., Shoaib, A., Chew-Graham, C., & Mamas, M. Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes

Background
Severe mental illness (SMI) is associated with an increased risk of cardiovascular disease and mortality. However, it is unclear whether SMI patients are just as likely to receive guideline-recommended therapy for AMI as those without men... Read More about Acute myocardial infarction in several mental illness: a nationwide analysis of prevalence, management strategies and outcomes.

Corrigendum to ``Pharmacological interventions for prevention of depression in high risk conditions: Systematic review and meta-analysis.'' Journal of Affective Disorders Volume 269, 15 May 2020, Pages 58-69. (2020)
Journal Article
Farooq, S., Singh, S. P., Burke, D., Naeem, F., & Ayub, M. (2020). Corrigendum to ``Pharmacological interventions for prevention of depression in high risk conditions: Systematic review and meta-analysis.'' Journal of Affective Disorders Volume 269, 15 May 2020, Pages 58-69. Journal of Affective Disorders, 274, 1216. https://doi.org/10.1016/j.jad.2020.05.068

Culturally adapted trauma-focused CBT-based guided self-help (CatCBT GSH) for female victims of domestic violence in Pakistan: feasibility randomized controlled trial. (2020)
Journal Article
Farooq. (2020). Culturally adapted trauma-focused CBT-based guided self-help (CatCBT GSH) for female victims of domestic violence in Pakistan: feasibility randomized controlled trial. Behavioural and Cognitive Psychotherapy, 50-61. https://doi.org/10.1017/S1352465820000685

BACKGROUND: Cognitive behaviour therapy (CBT), self-help and guided self-help interventions have been found to be efficacious and cost effective for victims of trauma, but there are limited data from low- and middle-income countries on culturally ada... Read More about Culturally adapted trauma-focused CBT-based guided self-help (CatCBT GSH) for female victims of domestic violence in Pakistan: feasibility randomized controlled trial..

Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial. (2020)
Journal Article
Farooq. (2020). Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial. British Journal of Psychiatry, 623-629. https://doi.org/10.1192/bjp.2020.138

BACKGROUND: With the development of evidence-based interventions for treatment of priority mental health conditions in humanitarian settings, it is important to establish the cost-effectiveness of such interventions to enable their scale-up. AIMS: To... Read More about Cost-effectiveness of WHO Problem Management Plus for adults with mood and anxiety disorders in a post-conflict area of Pakistan: randomised controlled trial..

Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan (2020)
Journal Article
Shepherd, T. A., Ul-Haq, Z., Ul-Haq, M., Firaz Khan, M., Afridi, A., Dikomitis, L., Robinson, M. E., Lewis, M., Rahman, A., Dziedzic, K., Saeed, U., Riaz Awan, N., Mallen, C., & Farooq, S. (2020). Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan. BMJ Open, 10(6), https://doi.org/10.1136/bmjopen-2019-034709

Introduction: There is a significant treatment gap, with only a few community-based services for people with schizophrenia in Low- and Middle-Income countries. Poor treatment adherence in schizophrenia is associated with poorer health outcomes, suici... Read More about Supervised treatment in outpatients for schizophrenia plus (STOPS+): protocol for a cluster randomised trial of a community-based intervention to improve treatment adherence and reduce the treatment gap for schizophrenia in Pakistan.

Pharmacological interventions for prevention of depression in high risk conditions: Systematic review and meta-analysis. (2020)
Journal Article
Farooq. (2020). Pharmacological interventions for prevention of depression in high risk conditions: Systematic review and meta-analysis. Journal of Affective Disorders, 58 - 69. https://doi.org/10.1016/j.jad.2020.03.024

BACKGROUND: Background Depressive disorders account for almost half of all Disability Adjusted Life Years caused by psychiatric disorders but efficacy of pharmacological interventions to prevent depressive disorders is not known. We aimed to assess e... Read More about Pharmacological interventions for prevention of depression in high risk conditions: Systematic review and meta-analysis..

Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview (2020)
Journal Article
Farooq. (2020). Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview. Indian Journal of Psychological Medicine, 4-10. https://doi.org/10.4103/IJPSYM.IJPSYM_379_19

Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach the therapeutic range (350 ng/ml). Thus, serum clozapine concentration-to-dos... Read More about Do Asian Patients Require Only Half of the Clozapine Dose Prescribed for Caucasians? A Critical Overview.

Hospital preparedness for disaster and mass casualty management in Pakistan: A cross-sectional evaluation study (2019)
Journal Article
Ul-Haq, Z., Hussain Shah, B., Ishaq Khattak, M., Fazid, S., Basharat, S., Hayat Khan, S., Khan, F., Shahzad, H., Razzak, J., Farooq, S., & Huda, Q. (2019). Hospital preparedness for disaster and mass casualty management in Pakistan: A cross-sectional evaluation study. American Journal of Disaster Medicine, 14(3), https://doi.org/10.5055/ajdm.2019.0330

Background: World Health Organization has advocated preemptive readiness of health systems to manage disastrous events. Pakistan is known to be highly susceptible to disasters on the one hand and significantly lacking in coping ability on the other.... Read More about Hospital preparedness for disaster and mass casualty management in Pakistan: A cross-sectional evaluation study.

Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records. (2019)
Journal Article
Chen, Y., Farooq, S., Edwards, J., Chew-Graham, C. A., Shiers, D., Frisher, M., Hayward, R., Sumathipala, A., & Jordan, K. P. (2019). Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records. BMC Medicine, 17, Article 227. https://doi.org/10.1186/s12916-019-1462-y

Background: The nature of symptoms in the prodromal period of first episode psychosis (FEP) remains unclear. The objective was to determine patterns of symptoms recorded in primary care in the 5-years before FEP diagnosis.

Methods: The study was s... Read More about Patterns of symptoms before a diagnosis of first episode psychosis: a latent class analysis of UK primary care electronic health records..