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Christine Roffe's Outputs (76)

The association between early neurological deterioration and whole blood purine concentration during acute stroke (2019)
Journal Article
Roffe. (2019). The association between early neurological deterioration and whole blood purine concentration during acute stroke. Biomarker Research, https://doi.org/10.1186/s40364-019-0158-y

Background
Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which accumulate during acute hypoxi... Read More about The association between early neurological deterioration and whole blood purine concentration during acute stroke.

Point-of-care measurements reveal release of purines into venous blood of stroke patients (2019)
Journal Article
Roffe. (2019). Point-of-care measurements reveal release of purines into venous blood of stroke patients. Purinergic Signalling, 237-246. https://doi.org/10.1007/s11302-019-09647-4

Stroke is a leading cause of death and disability. Here, we examine whether point-of-care measurement of the purines, adenosine, inosine and hypoxanthine, which are downstream metabolites of ATP, has potential to assist the diagnosis of stroke. In a... Read More about Point-of-care measurements reveal release of purines into venous blood of stroke patients.

The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes (2019)
Journal Article
Roffe. (2019). The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes. Health Research Policy and Systems, 1-8. https://doi.org/10.1186/s12961-019-0417-2

Background: The English National Institute for Health Research Clinical Research Network first established Hyperacute Stroke Research Centres (HSRCs) in 2010 to support multicentre hyperacute (< 9 h) and complex stroke research. We assessed the impac... Read More about The National Institute for Health Research Hyperacute Stroke Research Centres and the ENCHANTED trial: the impact of enhanced research infrastructure on trial metrics and patient outcomes.

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial (2018)
Journal Article
Roffe. (2018). Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet, 2107-2115. https://doi.org/10.1016/S0140-6736%2818%2931033-X

Background
Tranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage... Read More about Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial. (2018)
Journal Article
Roffe. (2018). Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial. Translational Stroke Research, 120 -129. https://doi.org/10.1007/s12975-017-0548-0

Post-stroke dysphagia is common, associated with poor outcome and often requires non-oral feeding/fluids. The relationship between route of feeding and outcome, as well as treatment with glyceryl trinitrate (GTN), was studied prospectively. The Effic... Read More about Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial..

Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT. (2018)
Journal Article
Bishop, J., Sim, J., Penaloza, C., Jowett, S., Gray, R., Ferdinand, P., …Roffe, C. (2018). Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT. Health Technology Assessment, 22(14), 1 - 88. https://doi.org/10.3310/hta22140

BACKGROUND: Stroke is a major cause of death and disability worldwide. Hypoxia is common after stroke and is associated with worse outcomes. Oxygen supplementation could prevent hypoxia and secondary brain damage. OBJECTIVES: (1) To assess whether or... Read More about Routine low-dose continuous or nocturnal oxygen for people with acute stroke: three-arm Stroke Oxygen Supplementation RCT..

Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. (2017)
Journal Article
Sim, J., Bishop, J., Gray, R., and the Stroke Oxygen Study Collaborative Group, S. O. S. I., Roffe, C., Nevatte, T., …Ferdinand, P. (2017). Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. Journal of the American Medical Association, 318(12), 1125 - 1135. https://doi.org/10.1001/jama.2017.11463

Importance: Hypoxia is common in the first few days after acute stroke, is frequently intermittent, and is often undetected. Oxygen supplementation could prevent hypoxia and secondary neurological deterioration and thus has the potential to improve r... Read More about Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial..

Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics (2017)
Journal Article
Behrouz, R., Masjuán-Vallejo, J., Vera, R., Willey, J. Z., Zedet, M., Moulin, S., …Di Napoli, M. (2018). Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics. Journal of Stroke and Cerebrovascular Diseases, 27(1), 246-256. https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.08.031

Background
Nonagenarians are under-represented in thrombolytic trials for acute ischemic stroke (AIS). The effectiveness of intravenous thrombolytics in nonagenarians in terms of safety and outcome is not well established.

Materials and Methods... Read More about Outcomes of Nonagenarians with Acute Ischemic Stroke Treated with Intravenous Thrombolytics.

Management of Acute Stroke in the Older Person. (2017)
Journal Article
Parr, E., Ferdinand, P., & Roffe, C. (2017). Management of Acute Stroke in the Older Person. Geriatrics, 2(3), Article 27. https://doi.org/10.3390/geriatrics2030027

The majority of people who suffer a stroke are older adults. The last two decades have brought major progress in the diagnosis and management of stroke, which has led to significant reductions in mortality, long-term disability, and the need for inst... Read More about Management of Acute Stroke in the Older Person..

Hypoxia after stroke: a review of experimental and clinical evidence (2016)
Journal Article
Ferdinand, P., & Roffe, C. (2016). Hypoxia after stroke: a review of experimental and clinical evidence. Experimental and Translational Stroke Medicine, 8, Article 9. https://doi.org/10.1186/s13231-016-0023-0

Background
Hypoxia is a common occurrence following stroke and associated with poor clinical and functional outcomes. Normal oxygen physiology is a finely controlled mechanism from the oxygenation of haemoglobin in the pulmonary capillaries to its d... Read More about Hypoxia after stroke: a review of experimental and clinical evidence.

Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study (2016)
Journal Article
Roffe. (2016). Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study. https://doi.org/10.1016/j.phmed.2016.11.001

Acute Ischemic Stroke (AIS) is the major type of stroke occurring in patients. Aspiration thrombectomy, which uses suction to remove the thrombosis, is a promising technique in the clinical treatment of AIS patients. In this research a computational... Read More about Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study.

Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract) (2016)
Journal Article
Gilchrist, & Roffe. (2016). Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract). European Respiratory Journal, https://doi.org/10.1183/13993003.congress-2016.PA4156

Background
The extent of respiratory compromise following a stroke depends on any pre-existing respiratory illness and the aetiology, location and extent of the lesion. Acquired respiratory infection in subsequent days may alter respiratory function... Read More about Structured light plethysmography measures asynchronous breathing patterns in patients with acute stroke (Meeting Abstract).

Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force (2016)
Journal Article
Roffe. (2016). Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force. European Respiratory Journal, 992-1018. https://doi.org/10.1183/13993003.01975-2015

Sleep disordered breathing (SDB) is a leading cause of morbidity worldwide. Its prevalence increases with age. Due to the demographic changes in industrial societies, pulmonologists and sleep physicians are confronted with a rapidly growing number of... Read More about Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force.

Clinical risk scores for predicting stroke-associated pneumonia: A systematic review (2016)
Journal Article
Roffe. (2016). Clinical risk scores for predicting stroke-associated pneumonia: A systematic review. European Stroke Journal, 76 - 84. https://doi.org/10.1177/2396987316651759

Purpose
Several risk stratification scores for predicting stroke-associated pneumonia have been derived. We aimed to evaluate the performance and clinical usefulness of such scores for predicting stroke-associated pneumonia.

Method
A systematic... Read More about Clinical risk scores for predicting stroke-associated pneumonia: A systematic review.

Validation and Recalibration of Two Multivariable Prognostic Models for Survival and Independence in Acute Stroke (2016)
Journal Article
Sim, J., Teece, L., Dennis, M. S., & Roffe, C. (2016). Validation and Recalibration of Two Multivariable Prognostic Models for Survival and Independence in Acute Stroke. PloS one, 11(5), Article ARTN e0153527. https://doi.org/10.1371/journal.pone.0153527

Introduction
Various prognostic models have been developed for acute stroke, including one based on age and five binary variables (‘six simple variables’ model; SSVMod) and one based on age plus scores on the National Institutes of Health Stroke Sca... Read More about Validation and Recalibration of Two Multivariable Prognostic Models for Survival and Independence in Acute Stroke.

Determinants and outcomes of stroke following percutaneous coronary intervention by indication (2016)
Journal Article
Roffe, & Mamas. (2016). Determinants and outcomes of stroke following percutaneous coronary intervention by indication. Stroke, 1500-1507. https://doi.org/10.1161/strokeaha.116.012700

Background and Purpose—Stroke after percutaneous coronary intervention (PCI) is a serious complication, but its determinants and outcomes after PCI in different clinical settings are poorly documented.

Methods—The British Cardiovascular Interventi... Read More about Determinants and outcomes of stroke following percutaneous coronary intervention by indication.

Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke (2016)
Journal Article
Roffe. (2016). Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke. New England Journal of Medicine, 2313-2323. https://doi.org/10.1056/NEJMoa1515510

BACKGROUND
Thrombolytic therapy for acute ischemic stroke with a lower-than-standard dose of intravenous alteplase may improve recovery along with a reduced risk of intracerebral hemorrhage.

METHODS
Using a 2-by-2 quasi-factorial open-label desi... Read More about Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke.

Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial (2016)
Journal Article
Roffe. (2016). Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial. International Journal of Stroke, 683-694. https://doi.org/10.1177/1747493016641960

Rationale
Outcome after intracerebral hemorrhage remains poor. Tranexamic acid is easy to administer, readily available, inexpensive, and effective in other hemorrhagic conditions.

Aim
This randomized trial aims to test the hypothesis that intra... Read More about Intravenous tranexamic acid for hyperacute primary intracerebral hemorrhage: Protocol for a randomized, placebo-controlled trial.

Post-stroke dysphagia: A review and design considerations for future trials (2016)
Journal Article
Roffe. (2016). Post-stroke dysphagia: A review and design considerations for future trials. International Journal of Stroke, 399 - 411. https://doi.org/10.1177/1747493016639057

Post-stroke dysphagia (a difficulty in swallowing after a stroke) is a common and expensive complication of acute stroke and is associated with increased mortality, morbidity, and institutionalization due in part to aspiration, pneumonia, and malnutr... Read More about Post-stroke dysphagia: A review and design considerations for future trials.