Outputs (10)

The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood (2016)
Journal Article
Hulme, C., Brown, S., Fuller, H., Riddell, J., Osman, A., Chowdhury, J., …Wright, K. (2017). The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood. Spinal Cord, 55, 114-125. https://doi.org/10.1038/sc.2016.174

Objectives: The identification of prognostic biomarkers of spinal cord injury (SCI) will help to assign SCI patients to the correct treatment and rehabilitation regimes. Further, the detection of biomarkers that predict permanent neurological outcom... Read More about The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood.

Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies (2016)
Journal Article
Owen, S., Jones, P., Caterson, B., Shirran, S., Fuller, H., Botting, C., & Roberts, S. (2016). Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies. Bioscience Reports, https://doi.org/10.1042/BSR20160465

This paper reports the perplexing results that came about because of seriously impure commercially available reagents. Commercial reagents and chemicals are routinely ordered by scientists and are expected to have been rigorously assessed for their p... Read More about Contaminants in Commercial Preparations of ‘Purified’ Small Leucine-Rich Proteoglycans May Distort Mechanistic Studies.

Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia (2016)
Journal Article
Mladinov, M., Sedmak, G., Fuller, H., Babić Leko, M., Mayer, D., Kirincich, J., …Šimić, G. (2016). Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia. Translational Neuroscience, https://doi.org/10.1515/tnsci-2016-0021

Schizophrenia is a complex polygenic disorder of unknown etiology. Over 3,000 candidate genes associated with schizophrenia have been reported, most of which being mentioned only once. Alterations in cognitive processing - working memory, metacogniti... Read More about Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia.

Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs) (2016)
Journal Article
Liddell, S., Fuller, H., Stanley, R., Schramm, G., Igetei, J., Doenhoff, M., & El-Faham, M. (2016). Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs). PloS one, https://doi.org/10.1371/journal.pone.0159542

IgG antibodies produced by rabbits immunized against S. mansoni antigens cross-reacted with aqueous soluble constituents of a variety of allergens. The antibody cross-reactivity was largely sensitive to degradation by treatment of the target antigens... Read More about Cross-Reactivity between Schistosoma mansoni Antigens and the Latex Allergen Hev b 7: Putative Implication of Cross-Reactive Carbohydrate Determinants (CCDs).

Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation (2016)
Journal Article
Fuller, H., Graham, L., Llavero Hurtado, M., & Wishart, T. (2016). Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation. Expert Review of Proteomics, 659-671. https://doi.org/10.1080/14789450.2016.1202768

Introduction: Proteomic techniques offer insights into the molecular perturbations occurring in muscular-dystrophies (MD). Revisiting published datasets can highlight conserved downstream molecular alterations, which may be worth re-assessing to dete... Read More about Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation.

Monoclonal antibody Py recognizes neurofilament heavy chain and is a selective marker for large diameter neurons in the brain Brain Structure and Function (2016)
Journal Article
Fuller, H. R., Marani, L., Holt, I., Woodhams, P. L., Webb, M. M., & Gates, M. A. (2016). Monoclonal antibody Py recognizes neurofilament heavy chain and is a selective marker for large diameter neurons in the brain Brain Structure and Function. Brain Structure and Function, 807-879. https://doi.org/10.1007/s00429-016-1252-7

Almost 30 years ago, the monoclonal antibody Py was developed to detect pyramidal neurons in the CA3 region of the rat hippocampus. The utility of this antibody quickly expanded when several groups discovered that it could be used to identify very sp... Read More about Monoclonal antibody Py recognizes neurofilament heavy chain and is a selective marker for large diameter neurons in the brain Brain Structure and Function.

Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy (2016)
Journal Article
Fuller, H., Wishart, T., & Gillingwater, T. (2016). Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy. Neuromuscular Disorders, 560-569. https://doi.org/10.1016/j.nmd.2016.06.004

The neuromuscular disease spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting from low levels of full-length survival motor neuron (SMN) protein. Despite having a good understanding of the underlying genetics of SM... Read More about Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy.

Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells (2016)
Journal Article
Wilson, E., Garton, M., & Fuller, H. (2016). Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells. Epilepsy Research, 97-101. https://doi.org/10.1016/j.eplepsyres.2016.03.002

Phenytoin is an antiepileptic drug used in the management of partial and tonic-clonic seizures. In previous studies we have shown that valproate, another antiepileptic drug, reduced the amount of two key bone proteins, pro-collagen I and osteonectin... Read More about Anti-epileptic drugs and bone loss: phenytoin reduces pro-collagen I and alters the electrophoretic mobility of osteonectin in cultured bone cells.

Abstract P4-10-14: Breast reconstruction changes coping mechanisms in breast cancer survivorship (2016)
Journal Article
Lake, B., Fuller, H., Rastall, S., & Usman, T. (2016). Abstract P4-10-14: Breast reconstruction changes coping mechanisms in breast cancer survivorship. Cancer Research, 76(4_Supplement), P4-10-14-P4-10-14. https://doi.org/10.1158/1538-7445.sabcs15-p4-10-14

Introduction Cancer survivorship is the process of living through and beyond cancer; a key part is how a patient copes with their diagnosis. Breast cancer is the most common malignancy of women worldwide and is known to be a severe stressor. Resea... Read More about Abstract P4-10-14: Breast reconstruction changes coping mechanisms in breast cancer survivorship.

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development (2016)
Journal Article
Fuller, H., Mandefro, B., Shirran, S., Gross, A., Kaus, A., Botting, C., …Sareen, S. (2016). Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development. Frontiers in Cellular Neuroscience, https://doi.org/10.3389/fncel.2015.00506

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced... Read More about Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development.