Outputs (2)
Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine. (2012)
Journal Article
BH3 mimetics such as ABT-737 and navitoclax bind to the BCL-2 family of proteins and induce apoptosis through the intrinsic apoptosis pathway. There is considerable variability in the sensitivity of different cells to these drugs. Understanding the m... Read More about Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine..