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The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer (2024)
Journal Article
Chang, S., Yang, Q., Liu, J., Yin, L., Han, J., Zong, L., & Pu, X. (in press). The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer. Molecules, 29(8), Article 1769. https://doi.org/10.3390/molecules29081769

The aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral absorption. A laboratory-scale microprecipitation–high-pressure homogenization method was e... Read More about The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer.

Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions (2019)
Journal Article
Yuan, Q., Wang, Y., Song, R., Hou, X., Yu, K., Zheng, J., …Zong, L. (2019). Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions. Frontiers in Pharmacology, 10, 225 -225. https://doi.org/10.3389/fphar.2019.00225

The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension compared with a true solution, which may in turn affect the therapeutic effect of the drug. The goal of this study was to prepare itraconazole nanosuspensions (... Read More about Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions.

Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(ß-Benzyl-L-aspartate) (PEG-PBLA) (2017)
Journal Article
Zong, L., Li, X., Wang, H., Cao, Y., Yin, L., Li, M., …Han, J. (2017). Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(ß-Benzyl-L-aspartate) (PEG-PBLA). International Journal of Pharmaceutics, 531(1), 108-117. https://doi.org/10.1016/j.ijpharm.2017.08.082

Abstract Amphiphilic block copolymers, PEG-PBLA with different molecular weights, were synthesized and used as new stabilizers for Itraconazole nannosuspensions (ITZ-PBLA-Nanos). ITZ-PBLA-Nanos were prepared by the microprecipitation-high pressure ho... Read More about Formulation and characterization of biocompatible and stable I.V. itraconazole nanosuspensions stabilized by a new stabilizer polyethylene glycol-poly(ß-Benzyl-L-aspartate) (PEG-PBLA).

Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology (2013)
Journal Article
Guan, J., Han, J., Zhang, D., Chu, C., Liu, H., Sun, J., …Zhang, T. (2014). Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology. European Journal of Pharmaceutics and Biopharmaceutics, 86(3), 376-382. https://doi.org/10.1016/j.ejpb.2013.10.008

The aim of this study was to design a silica-supported solid dispersion of a water-insoluble drug, glyburide, to increase its dissolution rate and oral absorption using supercritical fluid (SCF) technology. DSC and PXRD results indicated that the enc... Read More about Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology.