Skip to main content

Research Repository

Advanced Search

Paul Horrocks' Outputs (9)

Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger. (2022)
Journal Article
Luo, J., Mobley, R., Woodfine, S., Drijfhout, F., Horrocks, P., Ren, X., & Li, W. (2022). Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger. Applied Microbiology and Biotechnology, 106, 2433-2444. https://doi.org/10.1007/s00253-022-11888-0

Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate their in vitro antimalarial activity. A panel of microo... Read More about Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger..

Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum (2022)
Journal Article
Anagu, L. O., Hulse, D. R., Horrocks, P. D., & Chakravorty, S. J. (2022). Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum. Molecular and Biochemical Parasitology, 111458 - 111458. https://doi.org/10.1016/j.molbiopara.2022.111458

Background
In Plasmodium falciparum the monoallelic expression of var virulence genes is regulated through epigenetic mechanisms. A study in the Gambia showed that an increase in var gene expression is associated with fever, high blood lactate with... Read More about Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum.

Bullying and undermining: a threat to both patient care and medical personnel wellbeing? A cross sectional survey of the Undergraduates, trainees and consultants in Obstetrics and Gynaecology in the West Midlands (2015)
Journal Article
Parry-Smith, W., Morse, L., Sutherland, A., Horrocks, P., & O’Mahony, F. (2015). Bullying and undermining: a threat to both patient care and medical personnel wellbeing? A cross sectional survey of the Undergraduates, trainees and consultants in Obstetrics and Gynaecology in the West Midlands. MedEdPublish,

Lemierre's Syndrome: recognising a typical presentation of a rare condition (2015)
Journal Article
Horrocks. (2015). Lemierre's Syndrome: recognising a typical presentation of a rare condition. Case Reports in Infectious Diseases, 797415 -?. https://doi.org/10.1155/2015/797415

Lemierre's syndrome is a rare complication following an acute oropharyngeal infection. The aetiological agent is typically anaerobic bacteria of the genus Fusobacterium. The syndrome is characterised by a primary oropharyngeal infection followed by m... Read More about Lemierre's Syndrome: recognising a typical presentation of a rare condition.

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives (2013)
Journal Article
Horrocks, P., Pickard, M. R., Parekh, H. H., Patel, S. P., & Pathak, R. B. (2013). Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives. Organic and Biomolecular Chemistry, 11(29), 4891. https://doi.org/10.1039/c3ob27290g

3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an in... Read More about Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.

Functional analysis of the 5′ untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum (2013)
Journal Article
Hasenkamp, S., Russell, K., Ullah, I., & Horrocks, P. (2013). Functional analysis of the 5′ untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum. Acta tropica, 127(1), 69-74. https://doi.org/10.1016/j.actatropica.2013.03.007

Plasmodium falciparum transcripts contain long untranslated regions (UTR), with some of the longest in any eukaryote that uses monocistronic transcription. Owing to the extreme AT nucleotide bias within the intergenic regions that encode these UTR, a... Read More about Functional analysis of the 5′ untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum.