Paul Horrocks' Outputs (3)

The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest (2019)
Journal Article
Horrocks. (2019). The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest. Journal of Antimicrobial Chemotherapy, 362-370. https://doi.org/10.1093/jac/dkz443

Objectives: Rapid rate-of-kill (RoK) is a key parameter in the target candidate profile 1 (TCP1) for the next-generation antimalarial drugs for uncomplicated malaria, termed Single Encounter Radical Cure and Prophylaxis (SERCaP). TCP1 aims to rapidly... Read More about The relative rate of kill of the MMV Malaria Box compounds provide links to the mode of antimalarial action and highlight scaffolds of medicinal chemistry interest.

Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts (2019)
Journal Article
Horrocks. (2019). Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts. Frontiers in Plant Science, https://doi.org/10.3389/fpls.2019.00984

Artemisinin, a sesquiterpene lactone produced by Artemisia annua glandular secretory trichomes, is the active ingredient in the most effective treatment for uncomplicated malaria caused by Plasmodium falciparum parasites. Other metabolites in A. annu... Read More about Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts.

Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis (2019)
Journal Article
Aldulaimi, O., Drijfhout, F., Uche, F. I., Horrocks, P., & Li, W. (2019). Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis. BMC Complementary and Alternative Medicine, 183 -?. https://doi.org/10.1186/s12906-019-2589-2

BACKGROUND
Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts showed potent in vitro antiba... Read More about Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis.