Outputs (7)

Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway. (2022)
Journal Article
Mostafa, O., Sabry, D., Fouly, M., Ebrahim, N., El-Halim, H., Helal, O., El-Azab, N.-E., Badr, O., Hassouna, A., Saihati, H., Aborayah, N., Emam, H., El-Wakeel, H., Aljasir, M., El-Sherbiny, M., Sarg, N., Shaker, G., Forsyth, N., Elsherbiny, N., & Salim, R. (2022). Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway. Biomedicine and Pharmacotherapy, 113554 - ?. https://doi.org/10.1016/j.biopha.2022.113554

BACKGROUND: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management of DR. Exosomes, considered as a promising cell-free therapy optio... Read More about Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway..

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., Forsyth, N. R., Kehoe, O., & Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis (2021)
Presentation / Conference Contribution
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., Forsyth, N. R., & Kehoe, O. (2021, September). Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis. Poster presented at 6th European Congress of Immunology, Virtual meeting

Novel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion... Read More about Hypoxic and pro-inflammatory priming of mesenchymal stem cell-derived extracellular vesicles to reduce disease severity and immune responses in inflammatory arthritis.

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani  , I., Rudd  , T. R., Elli  , S., Gandhi  , N. S., Guimond  , S. E., Miller, G. J., Meneghetti, M. C., Nader, H. B., Li, Y., Nunes, Q. M., Procter, P., Mancini, N., Clementi, M., Bisio, A., Forsyth, N. R., Ferro, V., Turnbull  , J. E., Guerrini  , M., …Skidmore   , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes (2020)
Journal Article
Chen, L., Wang, C., Forsyth, N. R., & Wu, P. (2020). Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes. Stem Cell Research and Therapy, 11, Article 319. https://doi.org/10.1186/s13287-020-01828-y

Background
Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that extraembryonic stem cells in the placenta may also be affected during pregnancy. Neonatal tissue-d... Read More about Transcriptional profiling reveals altered biological characteristics of chorionic stem cells from women with gestational diabetes.

The in vitro effect of syndecan-3 gene knockout on bone marrow-derived mesenchymal stem cells' properties (2019)
Presentation / Conference Contribution
Stefan, A., Kay, A. . G., Forsyth, N., Jones, F. . K., Pisconti, A., & Kehoe, O. The in vitro effect of syndecan-3 gene knockout on bone marrow-derived mesenchymal stem cells' properties. Presented at Matrix Biology Europe – July 2018 Meeting Celebrating 50 years of Federation of European Connective Tissue Societies Meetings

Introduction: Inflammation is a central feature of rheumatoid arthritis that affects around 1% of the population and can result in disability and morbidity. The immunomodulatory effects of bone marrow-derived mesenchymal stem cells (MSCs) have been w... Read More about The in vitro effect of syndecan-3 gene knockout on bone marrow-derived mesenchymal stem cells' properties.

CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE (2018)
Presentation / Conference
Chen, L., Merkhan, M., Forsyth, N. R., & Wu, P. (2018, September). CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE. Poster presented at International Federation of Placenta Associations Meeting, Tokyo, Japan

Objectives: Chorionic and amniotic MSCs (CMSCs/AMSCs) are derived
from different sides of placental membrane. Women with a history of
gestational diabetes mellitus have a high risk of developing subsequent
diabetes. As cell therapy is a promising... Read More about CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE.