Outputs (5813)

Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway (2025)
Journal Article
Ebrahim, N., Al Saihati, H. A., Alali, Z., Mahmoud, S. Y. M., Rabaan, A. A., Dessouky, A. A., Salim, R. F., Shamaa, A. A., Abdallah, A. N., Elsherbiny, N. M., Othman, G., Badawy, A. A., Di Leva, G., & Badr, O. A. (2025). Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway. Current Stem Cell Research and Therapy, 16(1), Article 244. https://doi.org/10.1186/s13287-025-04284-8

Background: The JAK/STAT signaling pathway plays a crucial role in the release of interferons (IFNs) and the proinflammatory response during SARS-CoV-2 infection, contributing to the cytokine storm characteristic of severe COVID-19 cases. STAT3, a ke... Read More about Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway.

Type 2 diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records (2025)
Journal Article
Dyer, B. P., Burton, C., Rathod-Mistry, T., Blagojevic-Bucknall, M., & van der Windt, D. A. (2025). Type 2 diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records. BMC Musculoskeletal Disorders, 26(1), Article 471. https://doi.org/10.1186/s12891-025-08672-2

Objective: Estimate the effect of type 2 diabetes on the development of frozen shoulder and investigate whether the effect is mediated by other metabolic factors. Methods: Primary care medical record-based cohort study containing 43,977 people newly... Read More about Type 2 diabetes, metabolic health, and the development of frozen shoulder: a cohort study in UK electronic health records.

Healthcare use and its variation in people with fibromyalgia: a systematic review protocol (2025)
Journal Article
Katherine Byrne, A., Twohig, H., Muller, S., & C. Scott, I. (2025). Healthcare use and its variation in people with fibromyalgia: a systematic review protocol. Primary Health Care Research & Development, 26, 1-5. https://doi.org/10.1017/S1463423625000362

Aim:
A crucial step towards improving the care of people with fibromyalgia is understanding current practice. Our systematic review aims to address this by synthesising the global evidence around healthcare use in people with fibromyalgia, including... Read More about Healthcare use and its variation in people with fibromyalgia: a systematic review protocol.

Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial (2025)
Other
Thomas, M. J., Hughes, G., Cooke, K., Butler-Walley, S., Marshall, E., Bowyer, L., Wathall, S., Smith, J., Lawton, S. A., Brammar, J., Burnett, T., Drake, C., Foster, N. E., Hendry, G. J., Holden, M. A., Jaki, T., Joseph, R., Keenan, A.-M., Kigozi, J., Lewis, M., …Roddy, E. (2025). Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial

Background
Plantar heel pain (PHP) is the most common soft tissue foot condition and impairs mobility, physical function, ability to work, and quality of life. Systematic reviews highlight a need for high-quality randomised controlled trials (RCTs)... Read More about Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adaptive trial.

Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation (2025)
Journal Article
A Harrisson, S., Myers, H., Wynne Jones, G., Bajpai, R., Bratt, C., Burton, C., Harrison, R., Jowett, S., A Lawton, S., Saunders, B., J Beard, D., Bucknall, M., Chester, R., Heneghan, C., Huckfield, L., Lewis, M., D Mallen, C., Pincus, T., L Rees, J., Roddy, E., & A Van der Windt, D. (2025). Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation. BMJ Open, 15(5), https://doi.org/10.1136/bmjopen-2025-100501

Introduction: Musculoskeletal shoulder pain is a common reason for people to be treated in physiotherapy services, but diagnosis can be difficult and often does not guide treatment or predict outcome. People with shoulder pain cite a need for clear i... Read More about Clinical and cost-effectiveness of a personalised guided consultation versus usual physiotherapy care in people presenting with shoulder pain: a protocol for the PANDA-S cluster randomised controlled trial and process evaluation.

The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma (2025)
Journal Article
Usher, I., O'Donnell, P., Ligammari, L., Harder, D., Brown, W., Choi, D., Cool, P., Cottone, L., & Flanagan, A. M. (2025). The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma. The Journal of pathology, https://doi.org/10.1002/path.6427

The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNCTs) were a... Read More about The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma.

Discrimination of a single-item scale to measure intention to have a COVID-19 vaccine (2025)
Journal Article
Sim, J., Smith, L. E., Amlôt, R., Rubin, G. J., Sevdalis, N., & Sherman, S. M. (2025). Discrimination of a single-item scale to measure intention to have a COVID-19 vaccine. PloS one, 20(5), Article e0322503. https://doi.org/10.1371/journal.pone.0322503

Aim: When developing public health measures in a pandemic, it is important to examine attitudes and beliefs relating to vaccination uptake. We report the discrimination of a single-item vaccination intention scale and derive cutpoints in terms of sen... Read More about Discrimination of a single-item scale to measure intention to have a COVID-19 vaccine.

The everyday ethics in sterilization camps in India (2025)
Journal Article
Fiks, E. (2025). The everyday ethics in sterilization camps in India. Social Science and Medicine, 377, 118150. https://doi.org/10.1016/j.socscimed.2025.118150

This ethnographic paper examines how various professionals working within sterilization camps in India engage with everyday ethics. While sterilization in India—and its place within India's population control programme historically entrenched in over... Read More about The everyday ethics in sterilization camps in India.

Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2) (2025)
Journal Article
Geraghty, A. W. A., Becque, T., Roberts, L. C., Hill, J., Foster, N. E., Yardley, L., Stuart, B., Turner, D. A., Griffiths, G., Webley, F., Durcan, L., Morgan, A., Hughes, S., Bathers, S., Butler-Walley, S., Wathall, S., Mansell, G., White, M., Davies, F., & Little, P. (2025). Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2). Health Technology Assessment, 29(7), 1-112. https://doi.org/10.3310/gdps2418

Background Low back pain is highly prevalent and a leading cause of disability. Internet-delivered interventions may provide rapid and scalable support for behavioural self-management. There is a need to determine the effectiveness of highly accessib... Read More about Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2).

Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory (2025)
Journal Article
Rai, T., Hinton, L. E., Mackay, R., Black, M., Sanders, J., Slade, P., Elsmore, A., Dhadda, A., Parry-Smith, W., Collis, R., Petrou, S., Stanworth, S., Pallman, P., Townson, J., Fye, H., Geden, A. G., Collins, P., & Bell, S. (2025). Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory. PLoS ONE, 20(4), Article e0320754. https://doi.org/10.1371/journal.pone.0320754

Background: Post-partum haemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide. The Obstetric Bleeding Strategy (OBS) care bundle for PPH management was adopted into Welsh national guidelines in 2019 (as OBS Cymr... Read More about Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory.