Outputs (4)

GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. (2023)
Journal Article
Fardoun, M., Nasser, S. A., El-Yazbi, A. F., & Eid, A. H. (2023). GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. Journal of Cardiovascular Pharmacology, 82(6), 470-479. https://doi.org/10.1097/FJC.0000000000001489

Raynaud's phenomenon (RP), which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), the sole mediator of col... Read More about GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells..

Epac as a tractable therapeutic target (2023)
Journal Article
Slika, H., Mansour, H., Nasser, S., Shaito, A., Kobeissy, F., N. Orekhov, A., …Eid, A. (2023). Epac as a tractable therapeutic target. European Journal of Pharmacology, 945, Article 175645. https://doi.org/10.1016/j.ejphar.2023.175645

In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing attention given its multi... Read More about Epac as a tractable therapeutic target.

Inflammation and hypertension: Underlying mechanisms and emerging understandings. (2023)
Journal Article
Aboukhater, D., Morad, B., Nasrallah, N., Nasser, S. A., Sahebkar, A., Kobeissy, F., …Eid, A. H. (2023). Inflammation and hypertension: Underlying mechanisms and emerging understandings. Journal of Cellular Physiology, 238(6), 1148-1159. https://doi.org/10.1002/jcp.31019

Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive response against some homeostati... Read More about Inflammation and hypertension: Underlying mechanisms and emerging understandings..

Factors associated with infertility among the Lebanese population: a cross-sectional study (2023)
Journal Article
Dia, N., Mansour, S., Kharaba, Z., Malaeb, B., Sarray El Dine, A., Kokash, S., …Malaeb, D. (2023). Factors associated with infertility among the Lebanese population: a cross-sectional study. International Journal of Environmental Health Research, 34(2), 934-942. https://doi.org/10.1080/09603123.2023.2190084

The incidence of female infertility is growing worldwide and its rate varies across countries. . The goal of this study is to assess the rate of female infertility and identify its associated factors among Lebanese women. This cross-sectional study w... Read More about Factors associated with infertility among the Lebanese population: a cross-sectional study.