GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells.
(2023)
Journal Article
Fardoun, M., Nasser, S. A., El-Yazbi, A. F., & Eid, A. H. (2023). GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells. Journal of Cardiovascular Pharmacology, 82(6), 470-479. https://doi.org/10.1097/FJC.0000000000001489
Raynaud's phenomenon (RP), which results from exaggerated cold-induced vasoconstriction, is more prevalent in females than males. We previously showed that estrogen increases the expression of alpha 2C-adrenoceptors (α2C-AR), the sole mediator of col... Read More about GPER acts through the cAMP/Epac/JNK/AP-1 pathway to induce transcription of alpha 2C adrenoceptor in human microvascular smooth muscle cells..