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Outputs (623)

Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment? (2023)
Journal Article
Nicolson, P. J. A., & Holden, M. A. (2023). Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment?. Current Treatment Options in Rheumatology, 9(3), 120-131. https://doi.org/10.1007/s40674-023-00208-w

Purpose of review: Patient-centred care for people with osteoarthritis requires shared decision making. Understanding and considering patients’ preferences for osteoarthritis treatments is central to this. In this narrative review, we present an over... Read More about Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment?.

EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative synthesis. (2023)
Journal Article
May, C. R., Chew-Graham, C. A., Gallacher, K. I., Gravenhorst, K. C., Mair, F. S., Nolte, E., & Richardson, A. (in press). EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative synthesis. NIHR Open Research, 3, 31. https://doi.org/10.3310/nihropenres.13411.1

BackgroundThe workload health and social care service users and caregivers take on, and their capacity to do this work is important. It may play a key part in shaping the implementation of innovations in health service delivery and organisation; the... Read More about EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative synthesis..

Exploring the treatment burden of disease modifying anti rheumatic drug monitoring in people with rheumatoid arthritis (2023)
Journal Article
Ryan, S., Bullock, L., Manning, F., Chew-Graham, C. A., & Paskins, Z. (in press). Exploring the treatment burden of disease modifying anti rheumatic drug monitoring in people with rheumatoid arthritis. Rheumatology Advances in Practice, 7(2), Article rkad054. https://doi.org/10.1093/rap/rkad054

Objectives People with rheumatoid arthritis (RA) taking disease-modifying anti-rheumatic drugs (DMARDs) require safety monitoring to identify potential side-effects. This study aimed to explore patients’ and family members’ perspectives on DMARD moni... Read More about Exploring the treatment burden of disease modifying anti rheumatic drug monitoring in people with rheumatoid arthritis.

Risk of Venous Thromboembolism With Gout Flares (2023)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (2023). Risk of Venous Thromboembolism With Gout Flares. Arthritis and Rheumatology, 75(9), 1638-1647. https://doi.org/10.1002/art.42480

ObjectivePrevious studies demonstrated that the risk of venous thromboembolism (VTE) is increased in patients with gout, but not whether there was a temporal association between gout flare and VTE. This study was undertaken to evaluate potential temp... Read More about Risk of Venous Thromboembolism With Gout Flares.

Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo (2023)
Journal Article
Nafchi, N. A. M., Chilcott, E. M., Brown, S., Fuller, H. R., Bowerman, M., & Yáñez-Muñoz, R. J. (2023). Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo. Gene Therapy, https://doi.org/10.1038/s41434-023-00406-0

Spinal muscular atrophy (SMA) is a neuromuscular disease particularly characterised by degeneration of ventral motor neurons. Survival motor neuron (SMN) 1 gene mutations cause SMA, and gene addition strategies to replace the faulty SMN1 copy are a t... Read More about Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo.

Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis (2023)
Journal Article
Holden, M. A., Hattle, M., Runhaar, J., Riley, R. D., Healey, E. L., Quicke, J., …Exercise Collaborative, O. T. B. (2023). Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis. The Lancet Rheumatology, 5(7), e386-e400. https://doi.org/10.1016/S2665-9913%2823%2900122-4

Background Many international clinical guidelines recommend therapeutic exercise as a core treatment for knee and hip osteoarthritis. We aimed to identify individual patient-level moderators of the effect of therapeutic exercise for reducing pain an... Read More about Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis.

Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria (2023)
Journal Article
Nguyen, S. T., Du, D., Wychrij, D., Cain, M. D., Wu, Q., Klein, R. S., …Goldberg, D. E. (2023). Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America, 120(26), Article e2306318120. https://doi.org/10.1073/pnas.2306318120

Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication of malaria. HRPII has been sh... Read More about Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria.