Outputs (5420)

How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment? (2024)
Journal Article
Heald, A. H., Premawardhana, L. D., Taylor, P. N., Baker, A., Chaudhury, N., Fryer, A. A., …Stedman, M. (in press). How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?. Clinical Endocrinology, 1-6. https://doi.org/10.1111/cen.15185

Introduction: There continues to be much discussion around optimisation of thyroid hormone status in hypothyroid individuals. We here looked the way that free T4(FT4) and thyroid‐stimulating hormone (TSH) related to each other in a large laboratory s... Read More about How Does Thyroid Hormone Profile Differ on and Off Replacement Treatment?.

A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides (2024)
Journal Article
Shen, Z., Simard, M., Brand, D., Andrei, V., Al-Khader, A., Oumlil, F., …Collins-Fekete, C.-A. (in press). A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides. Communications Biology, 7(1), 1674. https://doi.org/10.1038/s42003-024-07398-6

Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incor... Read More about A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides.

Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review] (2024)
Journal Article
Imantalab, D., Singh Sokhal, B., Prasanna Kumar Menon, S., Kalra, S., Muller, S., & Mallen, C. (2024). Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-14. https://doi.org/10.3310/nihropenres.13786.1

Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 2... Read More about Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review].

Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022 (2024)
Journal Article
Ahmed, M., Nofal, A., Shafiq, A., Javaid, H., Ahsan, A., Nadeem, Z. A., …Fonarow, G. C. (in press). Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022. Journal of Diabetes Investigation, https://doi.org/10.1111/jdi.14386

Background: The prevalence of type 2 diabetes (T2D) and obesity are increasing in the United States. However, population‐level data for mortality trends due to T2D and obesity are limited. This study aims to assess these death trends among adults in... Read More about Rising mortality rates linked to type‐2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022.

Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI) (2024)
Journal Article
Bachmann, K. F., Jenkins, B., Asrani, V., Bear, D. E., Bolondi, G., Boraso, S., …Reintam Blaser, A. (in press). Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI). Critical Care, 28(1), 1-16. https://doi.org/10.1186/s13054-024-05192-8

Purpose: Gastrointestinal (GI) dysfunction is common in critically ill patients and associated with poor outcomes. There is a lack of standardised methods for daily monitoring of GI function. COSMOGI aimed to develop a Core Outcome Set (COS) for dail... Read More about Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI).

Use of sodium valproate and other antiseizure drug treatments in England and Wales: quantitative analysis of nationwide linked electronic health records (2024)
Journal Article
Dale, C. E., Takhar, R., Fan, Y. Y., Torabi, F., Katsoulis, M., Kim, S., …Sofat, R. (2024). Use of sodium valproate and other antiseizure drug treatments in England and Wales: quantitative analysis of nationwide linked electronic health records. BMJ Medicine, 3(1), 1-15. https://doi.org/10.1136/bmjmed-2023-000760

Objective: To investigate the use of sodium valproate in England and Wales, including during pregnancy, compared with other antiseizure drug treatments, based on national level electronic health records. Design: Quantitative analysis of nationwide li... Read More about Use of sodium valproate and other antiseizure drug treatments in England and Wales: quantitative analysis of nationwide linked electronic health records.

Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. (2024)
Journal Article
Migliorini, F., Schäfer, L., Pilone, M., Bell, A., Simeone, F., & Maffulli, N. (in press). Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis. Archives of Orthopaedic and Trauma Surgery, 145(1), 68. https://doi.org/10.1007/s00402-024-05614-w

The present meta-analysis compared the efficacy of intra-articular hyaluronic acid (HA) injections in patients with early to mild knee osteoarthritis (OA) (Kellgren Lawrence I-II) versus other commonly injected biologically active compounds using pat... Read More about Similar efficacy of intra-articular hyaluronic acid injections and other biologically active injections in patients with early stages knee osteoarthritis: a level I meta-analysis..

Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA) (2024)
Journal Article
Yeates, P., & McCray, G. (in press). Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA). BMC Medical Education, 24(1), 1466. https://doi.org/10.1186/s12909-024-06462-3

Introduction: Ensuring examiner equivalence across distributed assessment locations is a priority within distributed Objective Structured Clinical Exams (OSCEs) but is challenging as examiners are typically fully nested within locations (i.e. no over... Read More about Investigating the accuracy of adjusting for examiner differences in multi-centre Objective Structured Clinical Exams (OSCEs). A simulation study of video-based Examiner Score Comparison and Adjustment (VESCA).

Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey (2024)
Journal Article
Austin, R., Khair, E., Blakeman, T., Hossain, M. Z., Sowden, E., Chew-Graham, C., …Deaton, C. (2024). Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey. BMJ Open, 14(12), bmjopen-2024-092993. https://doi.org/10.1136/bmjopen-2024-092993

Aim: As heart failure (HF) with preserved ejection fraction (HFpEF) prevalence increases, it remains frequently underdiagnosed and poorly managed. Recent positive pharmacological trials have increased interest in HFpEF but challenges of diagnosis and... Read More about Diagnosing and managing patients with heart failure with preserved ejection fraction: a consensus survey.

What if the patient reads this? A student guide to writing in the GP electronic patient record (2024)
Journal Article
C, S., C, S., J, B., J, L., S, G., S C, S., …K, W. (in press). What if the patient reads this? A student guide to writing in the GP electronic patient record. Education for Primary Care, 1-6. https://doi.org/10.1080/14739879.2024.2435613

Background
It is common practice for senior medical students in UK General Practice to enter details of their consultations into the electronic patient record (EPR). There is evidence that students benefit educationally from writing in patient recor... Read More about What if the patient reads this? A student guide to writing in the GP electronic patient record.