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Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata (2016)
Journal Article
Uche, F., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. (2016). Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Li, W., & Richardson, A. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells (2016)
Journal Article
Abed, M., Abdullah, M., & Richardson, A. (2016). Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. Journal of Ovarian Research, 25 - ?. https://doi.org/10.1186/s13048-016-0234-y

BACKGROUND: BH3 mimetics are a class of drugs that antagonize the Bcl-2 family of apoptosis inhibitors. We have previously shown that these compounds can potentiate the activity of carboplatin against several ovarian cancer cell lines. However, recen... Read More about Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. (2016)
Journal Article
Stamelos, V. A., Fisher, N., Bamrah, H., Voisey, C., Price, J. C., Farrell, W. E., …Richardson, A. (in press). The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. PloS one, e0150696 - ?. https://doi.org/10.1371/journal.pone.0150696

Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that... Read More about The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization..

Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells (2015)
Journal Article
Kitchen, M. O., Yacqub-Usman, K., Emes, R. D., Richardson, A., Clayton, R. N., & Farrell, W. E. (2015). Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. Pituitary, 18(5), 674-684. https://doi.org/10.1007/s11102-014-0630-5

Introduction Transgenic mice overexpressing the high mobility group A (HMGA) genes, Hmga1 or Hmga2 develop pituitary tumours and their overexpression is also a frequent finding in human pituitary adenomas. In some cases, increased expression of HMGA... Read More about Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.

Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation (2014)
Journal Article
Robinson, E., Leung, E., Matuszek, A. M., Krogsgaard-Larsen, N., Furkert, D. P., Brimble, M. A., …Reynisson, J. (in press). Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation. MedChemComm, 6(1), 239-246. https://doi.org/10.1039/c4md00420e

Two hit compounds (14 and 62) were identified using virtual high throughput screening (vHTS) inhibiting the autophagy process in A2780 ovarian cancer cells. The expression levels of the LC3-II and p62 autophagy marker proteins were monitored using We... Read More about Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation.