Outputs (2252)

Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells (2025)
Journal Article
Citro, V., Clerici, M., Della Porta, G., Maffulli, N., Boccaccini, A. R., Dale, T. P., & Forsyth, N. R. (2025). Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells. Stem Cells International, 2025, Article 9047956. https://doi.org/10.1155/sci/9047956

Tendon tissue engineering draws on regenerative medicine principles, offering innovative solutions to address the challenges posed by tendon injuries and degenerative conditions. Tendons’ inherent limited regenerative capacity often hinders complete... Read More about Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells.

Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering (2025)
Journal Article
Citro, V., Clerici, M., Shephard, M. T., Dale, T. P., Boccaccini, A. R., & Forsyth, N. R. (2025). Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering. Advanced Materials Technologies, Article 2500246. https://doi.org/10.1002/admt.202500246

This study develops a biomaterial‐based strategy to address challenges in controlled growth factor delivery for tenogenic differentiation of mesenchymal stromal cells (MSCs) and tendon stem cells (TSCs). The 20% polycaprolactone (PCL) fibres, electro... Read More about Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering.

THE IMPACT OF SINGLE-SURGEON COMPARED TO DUAL-SURGEON APPROACH ON THE REDISLOCATION RATE FOLLOWING OPEN REDUCTION IN DEVELOPMENTAL DYSPLASIA OF THE HIP IN CHILDREN (2025)
Presentation / Conference Contribution
Segura, M., Cox, D., Horner, M., Clarke, M., Kiely, N., Freeman, R., & Williams, D. (2025, March). THE IMPACT OF SINGLE-SURGEON COMPARED TO DUAL-SURGEON APPROACH ON THE REDISLOCATION RATE FOLLOWING OPEN REDUCTION IN DEVELOPMENTAL DYSPLASIA OF THE HIP IN CHILDREN. Presented at The British Society for Children's Orthopaedic Surgery (BSCOS) 2025 Meeting, Brighton, England

IntroductionDevelopmental dysplasia of the hip (DDH) can be managed through a variety of different surgical approaches from closed reduction to simple tenotomies of the adductors and through to osteotomies of the femur and pelvis. The rate of redislo... Read More about THE IMPACT OF SINGLE-SURGEON COMPARED TO DUAL-SURGEON APPROACH ON THE REDISLOCATION RATE FOLLOWING OPEN REDUCTION IN DEVELOPMENTAL DYSPLASIA OF THE HIP IN CHILDREN.

Benign versus sinister aetiologies underlying basal cistern subarachnoid haemorrhage: a case series (2025)
Journal Article
Gravino, G., Abdelsalam, N., Patel, J., Aamir, S., Babatola, F., & Chandran, A. (in press). Benign versus sinister aetiologies underlying basal cistern subarachnoid haemorrhage: a case series. Journal of Medical Case Reports, 19(1), 1-15. https://doi.org/10.1186/s13256-024-04950-0

Background: Subarachnoid hemorrhage in the basal cisterns is usually identified on an unenhanced computed tomography scan of the head in patients presenting acutely with a characteristic sudden onset headache. Case presentation: Using imaging example... Read More about Benign versus sinister aetiologies underlying basal cistern subarachnoid haemorrhage: a case series.

Application of musculoskeletal modelling to evaluate movement and muscle activity patterns in shoulder instability (2025)
Thesis
Seyres, M. A. Application of musculoskeletal modelling to evaluate movement and muscle activity patterns in shoulder instability. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1109341

Shoulder instability is a complex impairment that presents as the shoulder sliding out of its support. It challenges current clinical practice in its definition, assessment, classification and long-term outcome. An improved understanding of its mecha... Read More about Application of musculoskeletal modelling to evaluate movement and muscle activity patterns in shoulder instability.

Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies (2025)
Thesis
Dimmock, R. L. Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1109999

The limbal epithelial stem cell (LESC) niche is a vital stem cell pool which serves to replenish the cornea with competent stem cells for regrowth and repair throughout adult life. Injury and disease, such as limbal stem cell deficiency (LSCD), can d... Read More about Simulation and characterization of the corneal limbal epithelial stem cell niche by using new biotechnologies.

A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome (2025)
Journal Article
Harrington, G. M. B., Cool, P., Hulme, C., Stokes-Fisher, J., Peffers, M., El Masri, W., Osman, A., Chowdhury, J. R., Kumar, N., Budithi, S., & Wright, K. (2025). A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome. Journal of Neurotrauma, 42(3-4), https://doi.org/10.1101/2022.07.12.499696

Spinal cord injury (SCI) is a major cause of disability, with complications postinjury often leading to lifelong health issues with the need for extensive treatment. Neurological outcome post-SCI can be variable and difficult to predict, particularly... Read More about A comprehensive proteomic and bioinformatics analysis of human spinal cord injury plasma identifies proteins associated with the complement cascade and liver function as potential prognostic indicators of neurological outcome.

Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells (2024)
Thesis
Alfred, K. I. Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1015802

Extracellular vesicles (EVs) are nanoscale, lipid-bound particles carrying bioactive molecules produced by cells. Mesenchymal stem cells (MSC) are preferred sources for producing therapeutically relevant EVs (MSC-EVs). Nonetheless, harnessing MSC-EVs... Read More about Development, characterisation and application of a novel nanofiber-based 3D technique for isolation, enrichment and purification of extracellular vesicles from mesenchymal stem cells.

Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model (2024)
Journal Article
Perry, J., Mennan, C., Cool, P., McCarthy, H., Newell, K., Hopkins, T., Hulme, C., Wright, K., Henson, F., & Roberts, S. (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage, https://doi.org/10.1177/19476035241287832

Objective
To determine if mesenchymal stromal cells (MSCs) derived from human umbilical cords (hUC) could reduce degeneration developing when injected into the knee of a large animal model of osteoarthritis (OA).
Design
Ten million culture-expande... Read More about Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.

Textile based medical devices and their role in sustainable health systems (2024)
Thesis
Morris, H. V. Textile based medical devices and their role in sustainable health systems. (Thesis). Keele University. https://keele-repository.worktribe.com/output/956321

The field of medical textiles is one of the fastest growing areas within the technical textiles sector of the textile industry. Part of this expansion is because of advances in technology, such as nanotechnology, electrospinning, and the ability to i... Read More about Textile based medical devices and their role in sustainable health systems.