Outputs (5)

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article
Roffe. (2019). Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage. Stroke, 3064 -3071. https://doi.org/10.1161/STROKEAHA.119.026389

Background and Purpose Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset. Methods We undertook a multicentre, paramedic-delivered, ambulance-based, prospective rando... Read More about Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage.

Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry (2019)
Journal Article
Roffe. (2019). Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry. Diabetes, db190440 - db190440. https://doi.org/10.2337/db19-0440

Available data from observational studies on the association of admission hyperglycaemia (aHG) with outcomes of acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) are contradictory especially when stratified by diabetes... Read More about Association of Baseline Hyperglycaemia with Outcomes of Diabetic and Non-diabetic Acute Ischaemic Stroke Patients treated with Intravenous Thrombolysis: A Propensity Score Matched Analysis from the SITS-ISTR Registry.

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT. (2019)
Journal Article
Roffe. (2019). Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT. Health Technology Assessment, 1 - 48. https://doi.org/10.3310/hta23350

BACKGROUND:Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. OBJECTIVE:The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneous in... Read More about Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT..

The association between early neurological deterioration and whole blood purine concentration during acute stroke (2019)
Journal Article
Roffe. (2019). The association between early neurological deterioration and whole blood purine concentration during acute stroke. Biomarker Research, https://doi.org/10.1186/s40364-019-0158-y

Background Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which accumulate during acute hypoxi... Read More about The association between early neurological deterioration and whole blood purine concentration during acute stroke.

Point-of-care measurements reveal release of purines into venous blood of stroke patients (2019)
Journal Article
Roffe. (2019). Point-of-care measurements reveal release of purines into venous blood of stroke patients. Purinergic Signalling, 237-246. https://doi.org/10.1007/s11302-019-09647-4

Stroke is a leading cause of death and disability. Here, we examine whether point-of-care measurement of the purines, adenosine, inosine and hypoxanthine, which are downstream metabolites of ATP, has potential to assist the diagnosis of stroke. In a... Read More about Point-of-care measurements reveal release of purines into venous blood of stroke patients.