Outputs (4)

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists (2014)
Journal Article

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identif... Read More about Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.

Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice (2014)
Journal Article

Male C57BL/6 mice fed ad libitum on control diet but allowed access to a palatable high fat diet (HFD) for 2?h a day during the mid-dark phase rapidly adapt their feeding behaviour and can consume nearly 80% of their daily caloric intake during this... Read More about Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice.

Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension (2014)
Journal Article

Growth hormone secretagogue receptor (GHS-R) signaling has been associated with growth hormone release, increases in food intake and pleiotropic cardiovascular effects. Recent data demonstrated that acute GHS-R antagonism leads to increases in mean a... Read More about Growth hormone secretagogue receptor deficiency in mice protects against obesity-induced hypertension.

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat (2014)
Journal Article

Providing rats and mice with access to palatable high fat diets for a short period each day induces the consumption of substantial binge-like meals. Temporal food intake structure (assessed using the TSE PhenoMaster/LabMaster system) and metabolic ou... Read More about Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat.