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Outputs (21)

Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in (2020)
Journal Article
Gilchrist. (2020). Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in. PloS one, https://doi.org/10.1371/journal.pone.0229300

INTRODUCTION: Lung clearance index (LCI) is a sensitive measure of early lung disease, but adoption into clinical practice has been slow. Challenges include the time taken to perform each test. We recently described a closed-circuit inert gas wash-in... Read More about Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in.

Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. (2019)
Journal Article
Gilchrist. (2019). Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review. BMJ Paediatrics Open, https://doi.org/10.1136/bmjpo-2019-000572

Background: Nusinersen has been used to treat spinal muscular atrophy type 1 (SMA1) in the UK since 2017. While initial trials showed neuromuscular benefit from treating SMA1, there is little information on the respiratory effects of nusinersen. We a... Read More about Healthcare utilisation in children with SMA type 1 treated with nusinersen: a single centre retrospective review..

Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres (2019)
Journal Article
Ditchfield, N., Carroll, W., & Gilchrist, F. (2019). Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2019.09.004

Highlights IV aminoglycosides are frequently used to treat infective exacerbations in CF due to efficacy against PA. The side effects of aminoglycosides include nephrotoxicity, ototoxicity and vestibulotoxicity. More than one third of UK CF... Read More about Unwarranted use of intravenous aminoglycosides at UK paediatric cystic fibrosis centres.

An approach to the child with a wet cough. (2019)
Journal Article
Gilchrist. (2019). An approach to the child with a wet cough. Paediatric Respiratory Reviews, 75-81. https://doi.org/10.1016/j.prrv.2018.11.002

When children have a wet cough, it suggests the presence of secretions in their airways. This often has an infectious aetiology which is usually a self-limiting viral infection requiring no investigation or treatment. In those with acute wet cough it... Read More about An approach to the child with a wet cough..

Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. (2018)
Journal Article
Gilchrist. (2018). Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. BMJ Paediatrics Open, e000367 - ?. https://doi.org/10.1136/bmjpo-2018-000367

Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocol... Read More about Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres..

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. (2018)
Journal Article
Gilchrist. (2018). Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, CD012798 - ?. https://doi.org/10.1002/14651858.CD012798.pub2

BACKGROUND: Cystic fibrosis is the most common life-limiting autosomal recessive genetic disorder in white populations. Distal intestinal obstruction syndrome (DIOS) is an important morbidity in cystic fibrosis. It is the result of the accumulation o... Read More about Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis..

Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children (2018)
Journal Article
Gilchrist. (2018). Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children. Physiological Reports, e13752. https://doi.org/10.14814/phy2.13752

Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breat... Read More about Tidal breathing parameters measured by structured light plethysmography in children aged 2-12 years recovering from acute asthma/wheeze compared with healthy children.

Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions (2017)
Journal Article
Gilchrist. (2017). Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions. Clinical and Experimental Allergy, 838-840. https://doi.org/10.1111/cea.12946

During childhood, exacerbation of asthma is the most common medical reason for admission to hospital in the UK. Each year 44,000 children are admitted to hospital in the UK with 40-50 children dying as a result of asthma [1]. Weather patterns and sea... Read More about Annual hospitalisation rates for children with asthma are inversely associated with total hours of sunshine in English regions.

Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator (2017)
Journal Article
Gilchrist. (2017). Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator. Physiological Reports, https://doi.org/10.14814/phy2.13168

Structured light plethysmography (SLP) is a light-based, noncontact technique that measures tidal breathing by monitoring displacements of the thoracoabdominal (TA) wall. We used SLP to measure tidal breathing parameters and their within-subject vari... Read More about Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator.