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Outputs (17)

PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review (2024)
Journal Article
Kirkby, M., Sabri, A. H. B., Holmes, A., Moss, G. P. J., & Scurr, D. (in press). PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review. Journal of Pharmacy and Pharmacology, 76(10), 1284–1300. https://doi.org/10.1093/jpp/rgae080

Objectives
Poly(amidoamine) dendrimers have been widely investigated as potential nanomaterials that can enhance the skin permeation of topically applied drugs. This article reviews the studies that have used dendrimers as penetration enhancers and... Read More about PAMAM dendrimers as mediators of dermal and transdermal drug delivery: a review.

Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution (2021)
Journal Article
Kirkby, M., Sabri, A. B., Scurr, D. J., & Moss, G. P. (2021). Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution. European Journal of Pharmaceutics and Biopharmaceutics, 159, 77-87. https://doi.org/10.1016/j.ejpb.2020.12.014

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide used in the UK as the first-line skin antiseptic prior to surgery in the UK due to its favourable efficacy and safety profile, high affinity for skin binding and minimal reports of resistance... Read More about Dendrimer-mediated permeation enhancement of chlorhexidine digluconate: Determination of in vitro skin permeability and visualisation of dermal distribution.

Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation (2020)
Journal Article
Moss. (2020). Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation. Journal of Pharmacy and Pharmacology, https://doi.org/10.1111/jphp.13263

Objectives The current study aims to determine the effect of physicochemical descriptor selection on models of polydimethylsiloxane permeation. Methods A total of 2942 descriptors were calculated for a data set of 77 chemicals. Data were processed to... Read More about Development of a Gaussian Process - feature selection model to characterise (poly)dimethylsiloxane (Silastic (R)) membrane permeation.

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article
Holmes, A. M., Heylings, J. R., Wan, K., & Moss, G. P. (2019). Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. International Journal of Antimicrobial Agents, 53(4), 500-507. https://doi.org/10.1016/j.ijantimicag.2018.12.012

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression (2018)
Journal Article
Moss. (2018). Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression. Journal of Pharmacy and Pharmacology, 361-373. https://doi.org/10.1111/jphp.12863

Objectives
The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters.

Methods
Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evoluti... Read More about Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression.

Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry (2017)
Journal Article
Holmes, A. M., Scurr, D. J., Heylings, J. R., Wan, K., & Moss, G. P. (2017). Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry. European Journal of Pharmaceutical Sciences, 104, 90-101. https://doi.org/10.1016/j.ejps.2017.03.034

Abstract Skin penetration and localisation of chlorhexidine digluconate (CHG) within the skin have been investigated in order to better understand and optimise the delivery using a nano polymeric delivery system of this topically-applied antimicrobia... Read More about Dendrimer pre-treatment enhances the skin permeation of chlorhexidine digluconate: Characterisation by in vitro percutaneous absorption studies and Time-of-Flight Secondary Ion Mass Spectrometry.

Pharmacy staff perspectives on the role of community pharmacy in the provision of first aid and responding to emergencies: a qualitative study. (2017)
Presentation / Conference Contribution
Liaskou, M., White, S., Moss, G., Ratcliffe, N., & Cook, J. (2017, April). Pharmacy staff perspectives on the role of community pharmacy in the provision of first aid and responding to emergencies: a qualitative study. Presented at Health Services Research and Pharmacy Practice Conference, University of Nottingham, UK

No abstract

Pharmacy students’ views on community pharmacy provision of first aid and responding to medical emergencies: a scenario-based questionnaire study (2016)
Presentation / Conference Contribution
Shah, P., White, S., Moss, G., & Ratcliffe, N. (2016, September). Pharmacy students’ views on community pharmacy provision of first aid and responding to medical emergencies: a scenario-based questionnaire study. Poster presented at Royal Pharmaceutical Society (RPS), Annual Conference 2016, ICC Birmingham, UK

Support vector regression to estimate the permeability enhancement of potential transdermal enhancers (2016)
Journal Article
Moss. (2016). Support vector regression to estimate the permeability enhancement of potential transdermal enhancers. Journal of Pharmacy and Pharmacology, 170-184. https://doi.org/10.1111/jphp.12508

Objectives
Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydro... Read More about Support vector regression to estimate the permeability enhancement of potential transdermal enhancers.