Outputs (35)

Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. (2013)
Journal Article
Jeon, Y., Nuovo, G. J., Midddleton, J., Joshi, P., Nazaryan, N., Di Leva, G., …Croce, C. M. (2013). Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. Cancer Research, 73(8_Supplement), LB-244-LB-244. https://doi.org/10.1158/1538-7445.am2013-lb-244

Lung cancer is the most common cause of cancer death worldwide. Despite years of research, the prognosis for patients with lung cancer remains dismal. The most frequent type, non-small cell lung cancer (NSCLC) (85%), shows an overall five year surviv... Read More about Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer..

Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. (2013)
Journal Article
Taccioli, C., Chen, H., Garofalo, M., Jiang, Y., Di Leva, G., Alder, H., …Fong, L. Y. Y. (2013). Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. Cancer Research, 73(8_Supplement), LB-241-LB-241. https://doi.org/10.1158/1538-7445.am2013-lb-241

Dietary zinc deficiency (ZD) is implicated in the pathogenesis of human esophageal squamous cell carcinoma (ESCC). microRNA-31 (miR-31) is overexpressed in human ESCC. In the rat a ZD diet promotes esophageal carcinogenesis by inducing cellular proli... Read More about Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats..

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. (2013)
Journal Article
Di Leva, G., Piovan, C., Gasparini, P., Ngankeu, A., Taccioli, C., Briskin, D., …Croce, C. M. (2013). Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLOS genetics, 9(3), Article ARTN e1003311. https://doi.org/10.1371/journal.pgen.1003311

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions have been characterized for some miRNAs, the majority of microRNAs have not b... Read More about Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status..

miRNA profiling of cancer (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). miRNA profiling of cancer. Current Opinion in Genetics and Development, 23(1), 3-11. https://doi.org/10.1016/j.gde.2013.01.004

A steadily growing number of studies have shown that microRNAs have key roles in the regulation of cellular processes and that their dysregulation is essential to keep the malignant phenotype of cancer cells. The distorted and unique expression profi... Read More about miRNA profiling of cancer.

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. (2012)
Journal Article
Di Leva. (2012). Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Molecular Oncology, 458 - 472. https://doi.org/10.1016/j.molonc.2012.03.003

An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA l... Read More about Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer..