Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology
(2013)
Journal Article
Guan, J., Han, J., Zhang, D., Chu, C., Liu, H., Sun, J., …Zhang, T. (2014). Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology. European Journal of Pharmaceutics and Biopharmaceutics, 86(3), 376-382. https://doi.org/10.1016/j.ejpb.2013.10.008
The aim of this study was to design a silica-supported solid dispersion of a water-insoluble drug, glyburide, to increase its dissolution rate and oral absorption using supercritical fluid (SCF) technology. DSC and PXRD results indicated that the enc... Read More about Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology.