DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems
(2012)
Journal Article
Hume, P. A., Brimble, M. A., & Reynisson, J. (2013). DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems. Computational and Theoretical Chemistry, 1005, 9-15. https://doi.org/10.1016/j.comptc.2012.10.022
Mitomycin C is a DNA alkylating agent activated by bioreduction. It has been in clinical use against a range of solid tumours since the 1960s. Its DNA adduct formation mechanism has been extensively studied and it therefore presents an excellent test... Read More about DNA adduct formation of mitomycin C. A test case for DFT calculations on model systems.